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FLASH GENE

Symbol

SPIB

contributors: mct - updated : 19-11-2010

HGNC name	Spi-B transcription factor (Spi-1/PU.1 related)
HGNC id	11242

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

ANIMAL & CELL MODELS

mice deficient in both Spib and Spi1 in the B-cell lineage had reduced frequencies of B cells as well as impaired B-cell differentiation, and developed pre-B cell acute lymphoblastic leukemia before 30 weeks of age