Selected-GenAtlas references	SOURCE	GeneCards	NCBI Gene	Swiss-Prot	Orphanet	Ensembl
	HGNC	UniGene	Nucleotide	OMIM		UCSC

Home Page

FLASH GENE

Symbol

SPIB

contributors: mct - updated : 19-11-2010

HGNC name	Spi-B transcription factor (Spi-1/PU.1 related)
HGNC id	11242

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

ASSOCIATED DISORDERS

corresponding disease(s)

Susceptibility

to primary biliary cirrhosis

Variant & Polymorphism SNP	rs3745516 within SPIB strongly associated with primary biliary cirrhosis

Candidate gene

Marker

Therapy target

ANIMAL & CELL MODELS

mice deficient in both Spib and Spi1 in the B-cell lineage had reduced frequencies of B cells as well as impaired B-cell differentiation, and developed pre-B cell acute lymphoblastic leukemia before 30 weeks of age