| basic FUNCTION
| extracellular calcium-binding protein, regulator of cell growth (osteonectin/BM40) and activator of MMP2 at the cell surface |
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contributing to the proteolytic pathway associated with tumor invasion |
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functioning as an endogenous inhibitor of cell proliferation, regulating angiogenesis, cell adhesion to extracellular matrix, binding cytokines such as platelet derived growth factor and stimulating transforming growth factor-beta (TGF-beta) production |
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invoved in the regulation of tumor growth, with THBS1 and FN1 |
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may modulate intercellular adhesion of basal limbal epithelial cells |
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potentiated apoptosis by increasing caspase-8 signaling |
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functions, in part, to promote tumor progression by enabling tumor cells to survive under stressful conditions |
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matricellular glycoprotein, mediating interactions between cells and their extracellular matrix, and playing a role in in extracellular matrix organization |
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involved in collagen fibrillogenesis |
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protects cells from stress-induced apoptosis via an interaction with integrin beta 1 heterodimers that enhances ILK activation and pro-survival activity |
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function as a tumor suppressor in ovarian cancer, pancreatic cancer and acute myeloid leukemia |
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molecular chaperone that guides the folding of basement membrane proteins |
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impairs the proliferation of different cell types and modulates tumor cell aggressive features  |
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matricellular protein that is highly expressed during development, tissue remodeling, and repair |
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suppresses apoptosis of idiopathic pulmonary fibrosis fibroblasts throug hconstitutive activation of beta catenin |
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secreted protein that binds to collagen type I in the extracellular space, it might also play a role as an intracellular chaperone of collagen type I |
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potentially important contributor to adipocyte differentiation and fat metabolism |
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involved in PRKAA1-regulation of glucose metabolism |
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strong inducer of autophagy as well as apoptosis |
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its expression induces autophagy, which results in the elevation of cathepsin B (CTSB) and subsequent mitochondria-mediated apoptosis |
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matrix cellular protein, which governs diverse cellular functions and has a pivotal role in regulating cell-matrix interactions, cellular proliferation and migration |
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promotes cellular deadhesion and motility in wound healing |
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participates in the regulation of morphogenesis and cellular differentiation through its modulation of cell-matrix interactions |
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induces potentially expression of neuronal markers in medulloblastoma cells through its inhibitory effect on IL6-regulated suppression of Notch pathway-mediated STAT3 signaling |
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SPARC functions through activation of AKT1 and MDM2 to limit TP53 levels |
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promotes pericyte migration by diminishing TGFB1 activity and identify a novel function for endoglin in controlling pericyte behavior |
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SPARC targets STAT3 signaling network induce growth arrest |
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secreted extracellular matrix glycoprotein with counter-adhesive properties, functioning to promote breast cancer invasion |
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matricellular protein with important roles in cell-extracellualr matrix interactions |
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regulator of microglial proliferation and structure, and may play an important role in differently regulating the gray and white matter microglial responses to CNS lesion--and modulating behavioral recovery--after injury |
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has a pathogenic role in the alteration of the extracellular matrix of intracranial arteries during aneurysm formation |
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may play an important role in the regulation of normal placentation by promoting the invasion of trophoblast cells into the uterine decidua |
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plays a crucial role in the regulation of early B lymphopoiesis |
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matricellular protein that is important for the regulation of cell growth and adhesion |
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stromal-derived matricellular protein SPARC is a novel regulator of islet survival and beta cell growth |
