| 1 | RGS4, SPARC
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| SPARC promotes insulin secretion through down-regulation of RGS4 protein in pancreatic β cells
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| Hu L, He F, Huang M, Zhao Q, Cheng L, Said N, Zhou Z, Liu F, Dai YS.
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| Sci Rep. Oct 16;10(1):17581. doi: 10.1038/s41598-020-74593-w. PMID: 2020
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| 2 | OIXVII, SPARC
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| Recessive Osteogenesis Imperfecta Caused by Missense Mutations in SPARC.
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| Mendoza-Londono R, Fahiminiya S, Majewski J; Care4Rare Canada Consortium, Tétreault M, Nadaf J, Kannu P, Sochett E, Howard A, Stimec J, Dupuis L, Roschger P, Klaushofer K, Palomo T, Ouellet J, Al-Jallad H, Mort JS, Moffatt P, Boudko S, Bächinger HP, Rauch F.
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| Am J Hum Genet 96(6):979-85. doi: 10.1016/j.ajhg.2015.04.021. Epub 2015 May 28. 2015
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| 3 | SPARC
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| Novel role for matricellular proteins in the regulation of islet β cell survival: the effect of SPARC on survival, proliferation, and signaling.
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| Ryall CL, Viloria K, Lhaf F, Walker AJ, King A, Jones P, Mackintosh D, McNeice R, Kocher H, Flodstrom-Tullberg M, Edling C, Hill NJ.
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| J Biol Chem 289(44):30614-24. doi: 10.1074/jbc.M114.573980. Epub 2014 Sep 9.
2014
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| 4 | SPARC
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| SPARC was overexpressed in human endometrial cancer stem-like cells and promoted migration activity.
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| Yusuf N, Inagaki T, Kusunoki S, Okabe H, Yamada I, Matsumoto A, Terao Y, Takeda S, Kato K.
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| Gynecol Oncol 134(2):356-63. doi: 10.1016/j.ygyno.2014.04.009. Epub 2014 Apr 25.
2014
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| 5 | SPARC
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| SPARC deficiency affects bone marrow stromal function, resulting in impaired B lymphopoiesis.
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| Luo Z, Zhou Y, Luo P, Zhao Q, Xiao N, Yu Y, Yan Q, Lu G, Cheng L.
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| J Leukoc Biol 96(1):73-82. doi: 10.1189/jlb.1A0713-415RR. Epub 2014 Mar 5.
2014
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| 6 | SPARC
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| SPARC promotes leukemic cell growth and predicts acute myeloid leukemia outcome.
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| Alachkar H, Santhanam R, Maharry K, Metzeler KH, Huang X, Kohlschmidt J, Mendler JH, Benito JM, Hickey C, Neviani P, Dorrance AM, Anghelina M, Khalife J, Tarighat SS, Volinia S, Whitman SP, Paschka P, Hoellerbauer P, Wu YZ, Han L, Bolon BN, Blum W, Mrózek K, Carroll AJ, Perrotti D, Andreeff M, Caligiuri MA, Konopleva M, Garzon R, Bloomfield CD, Marcucci G.
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| J Clin Invest 124(4):1512-24. doi: 10.1172/JCI70921. Epub 2014 Mar 3.
2014
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| 7 | MMP2, MMP9, SPARC
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| The expression of SPARC in human intracranial aneurysms and its relationship with MMP-2/-9.
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| Li B, Li F, Chi L, Zhang L, Zhu S.
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| PLoS One 8(3):e58490. doi: 10.1371/journal.pone.0058490. Epub 2013 Mar 14.
2013
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| 8 | SPARC
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| Downregulation of SPARC expression inhibits the invasion of human trophoblast cells in vitro.
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| Jiang Y, Zhu Y, Shi Y, He Y, Kuang Z, Sun Z, Wang J.
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| PLoS One 8(7):e69079. doi: 10.1371/journal.pone.0069079. Print 2013.
2013
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| 9 | SPARC
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| SPARC is up-regulated during skeletal muscle regeneration and inhibits myoblast differentiation.
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| Petersson SJ, Jørgensen LH, Andersen DC, Nørgaard RC, Jensen CH, Schrøder HD.
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| Histol Histopathol 28(11):1451-60. Epub 2013 May 14.
2013
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| 10 | SPARC
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| SPARC regulates microgliosis and functional recovery following cortical ischemia.
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| Lloyd-Burton SM, York EM, Anwar MA, Vincent AJ, Roskams AJ.
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| J Neurosci 33(10):4468-81. doi: 10.1523/JNEUROSCI.3585-12.2013.
2013
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| 11 | SPARC
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| SPARC fusion protein induces cellular adhesive signaling.
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| Cheng L, Sage EH, Yan Q.
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| PLoS One 8(1):e53202. doi: 10.1371/journal.pone.0053202. Epub 2013 Jan 21.
2013
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| 12 | CCNB1, SPARC, STAT3
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| SPARC expression induces cell cycle arrest via STAT3 signaling pathway in medulloblastoma cells.
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| Chetty C, Dontula R, Ganji PN, Gujrati M, Lakka SS.
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| Biochem Biophys Res Commun 417(2):874-9. doi: 10.1016/j.bbrc.2011.12.065. Epub 2011 Dec 20.
2012
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| 13 | ITGB4, SPARC
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| Integrin β4 regulates SPARC protein to promote invasion.
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| Gerson KD, Shearstone JR, Maddula VS, Seligmann BE, Mercurio AM.
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| J Biol Chem 287(13):9835-44. doi: 10.1074/jbc.M111.317727. Epub 2012 Feb 3.
2012
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| 14 | SPARC, STAB1, STAB2
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| Probing structural selectivity of synthetic heparin binding to Stabilin protein receptors.
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| Pempe EH, Xu Y, Gopalakrishnan S, Liu J, Harris EN.
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| J Biol Chem 287(25):20774-83. doi: 10.1074/jbc.M111.320069. Epub 2012 Apr 30. 2012
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| 15 | DCN, SPARC, SPRY1, TSKU
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| Stromal expression of decorin, Semaphorin6D, SPARC, Sprouty1 and Tsukushi in developing prostate and decreased levels of decorin in prostate cancer.
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| Henke A, Grace OC, Ashley GR, Stewart GD, Riddick AC, Yeun H, O'Donnell M, Anderson RA, Thomson AA.
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| PLoS One 7(8):e42516. doi: 10.1371/journal.pone.0042516. Epub 2012 Aug 3.
2012
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| 16 | SPARC
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| SPARC stimulates neuronal differentiation of medulloblastoma cells via the Notch1/STAT3 pathway.
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| Bhoopathi P, Chetty C, Dontula R, Gujrati M, Dinh DH, Rao JS, Lakka SS.
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| Cancer Res 71(14):4908-19. Epub 2011 May 25.
2011
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| 17 | SPARC, STAB1
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| Identification of a sequence in the matricellular protein SPARC that interacts with the scavenger receptor stabilin-1.
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| Workman G, Sage EH.
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| J Cell Biochem 112(4):1003-8. doi: 10.1002/jcb.23015.
2011
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| 18 | SPARC
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| SPARC promotes pericyte recruitment via inhibition of endoglin-dependent TGF-β1 activity.
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| Rivera LB, Brekken RA.
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| J Cell Biol 193(7):1305-19.
2011
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| 19 | SPARC, TP53INP1
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| TP53INP1 decreases pancreatic cancer cell migration by regulating SPARC expression.
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| Seux M, Peuget S, Montero MP, Siret C, Rigot V, Clerc P, Gigoux V, Pellegrino E, Pouyet L, N'Guessan P, Garcia S, Dufresne M, Iovanna JL, Carrier A, André F, Dusetti NJ.
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| Oncogene 30(27):3049-61. doi: 10.1038/onc.2011.25. Epub 2011 Feb 21.
2011
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| 20 | SPARC
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| SPARC functions as an anti-stress factor by inactivating p53 through Akt-mediated MDM2 phosphorylation to promote melanoma cell survival.
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| Fenouille N, Puissant A, Tichet M, Zimniak G, Abbe P, Mallavialle A, Rocchi S, Ortonne JP, Deckert M, Ballotti R, Tartare-Deckert S.
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| Oncogene 30(49):4887-900. doi: 10.1038/onc.2011.198. Epub 2011 Jun 20.
2011
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| 21 | SPARC, SPARCL1
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| Control of excitatory CNS synaptogenesis by astrocyte-secreted proteins Hevin and SPARC.
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| Kucukdereli H, Allen NJ, Lee AT, Feng A, Ozlu MI, Conatser LM, Chakraborty C, Workman G, Weaver M, Sage EH, Barres BA, Eroglu C.
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| Proc Natl Acad Sci U S A 108(32):E440-9. doi: 10.1073/pnas.1104977108.
2011
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| 22 | SPARC, SPARCL1
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| Effect of hevin deletion in mice and characterization in trabecular meshwork.
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| Kang MH, Oh DJ, Rhee DJ.
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| Invest Ophthalmol Vis Sci 52(5):2187-93. doi: 10.1167/iovs.10-5428.
2011
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| 23 | SPARC
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| SPARC suppresses apoptosis of idiopathic pulmonary fibrosis fibroblasts through constitutive activation of beta-catenin.
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| Chang W, Wei K, Jacobs SS, Upadhyay D, Weill D, Rosen GD.
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| J Biol Chem 285(11):8196-206. Epub 2010 Jan 8.PMID: 20061390 2010
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| 24 | PRKAA1, SPARC
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| SPARC interacts with AMPK and regulates GLUT4 expression.
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| Song H, Guan Y, Zhang L, Li K, Dong C.
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| Biochem Biophys Res Commun 396(4):961-6. Epub 2010 May 10. 2010
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| 25 | BID, CTSB, SPARC
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| Cathepsin B facilitates autophagy-mediated apoptosis in SPARC overexpressed primitive neuroectodermal tumor cells.
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| Bhoopathi P, Chetty C, Gujrati M, Dinh DH, Rao JS, Lakka S.
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| Cell Death Differ 17(10):1529-39. Epub 2010 Mar 26.
2010
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| 26 | SPARC, STAB1, STAB2
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| Stabilins are expressed in bone marrow sinusoidal endothelial cells and mediate scavenging and cell adhesive functions.
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| Qian H, Johansson S, McCourt P, Smedsrød B, Ekblom M, Johansson S.
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| Biochem Biophys Res Commun 390(3):883-6. doi: 10.1016/j.bbrc.2009.10.068. Epub 2009 Oct 20.
2009
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| 27 | SPARC
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| The copper binding domain of SPARC mediates cell survival in vitro via interaction with integrin beta1 and activation of integrin-linked kinase.
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| Weaver MS, Workman G, Sage EH.
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| J Biol Chem 283(33):22826-37. Epub 2008 May 23.
2008
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| 28 | SPARC
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| Mapping of SPARC/BM-40/osteonectin-binding sites on fibrillar collagens.
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| Giudici C, Raynal N, Wiedemann H, Cabral WA, Marini JC, Timpl R, Bchinger HP, Farndale RW, Sasaki T, Tenni R.
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| J Biol Chem 283(28):19551-60. Epub 2008 May 16. 2008
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| 29 | SPARC
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| SPARC modulates the proliferation of stromal but not melanoma cells unless endogenous SPARC expression is downregulated.
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| Haber CL, Gottifredi V, Llera AS, Salvatierra E, Prada F, Alonso L, Sage EH, Podhajcer OL.
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| Int J Cancer 122(7):1465-75. Erratum in: Int J Cancer. 2008 Jul 1;123(1):245. Helene, Sage E [corrected to Sage, E Helene]. PMID: 18059024 2008
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| 30 | SPARC
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| SPARC is expressed by macroglia and microglia in the developing and mature nervous system.
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| Vincent AJ, Lau PW, Roskams AJ.
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| Dev Dyn 237(5):1449-62.PMID: 18366138 2008
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| 31 | SPARC
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| Proteomic analysis of soluble factors secreted by limbal fibroblasts.
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| Shimmura S, Miyashita H, Higa K, Yoshida S, Shimazaki J, Tsubota K.
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| Mol Vis 12:478-84. 2006
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| 32 | SPARC, SPP1, THBS3
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| Effects of THBS3, SPARC and SPP1 expression on biological behavior and survival in patients with osteosarcoma.
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| Dalla-Torre CA, Yoshimoto M, Lee CH, Joshua AM, de Toledo SR, Petrilli AS, Andrade JA, Chilton-MacNeill S, Zielenska M, Squire JA.
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| BMC Cancer 6:237. 2006
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| 33 | SPARC
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| SPARC regulates extracellular matrix organization through its modulation of integrin-linked kinase activity.
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| Barker TH, Baneyx G, Cardo-Vila M, Workman GA, Weaver M, Menon PM, Dedhar S, Rempel SA, Arap W, Pasqualini R, Vogel V, Sage EH.
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| J Biol Chem 280(43):36483-93. Epub 2005 Aug 22. 2005
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| 34 | SPARC
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| Overexpression of SPARC gene in human gastric carcinoma and its clinic-pathologic significance.
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| Wang CS, Lin KH, Chen SL, Chan YF, Hsueh S.
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| Br J Cancer 91(11):1924-30. 2004
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| 35 | SPARC
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| Secreted protein acidic, rich in cysteine (SPARC), mediates cellular survival of gliomas through AKT activation.
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| Shi Q, Bao S, Maxwell JA, Reese ED, Friedman HS, Bigner DD, Wang XF, Rich JN.
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| J Biol Chem 279(50):52200-9. Epub 2004 Oct 5. 2004
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| 36 | THBS1, FN1, SPARC,THY1
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| THY1 expression is associated with tumor suppression of human ovarian cancer.
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| Abeysinghe HR, Cao Q, Xu J, Pollock S, Veyberman Y, Guckert NL, Keng P, Wang N.
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| Cancer Genet Cytogenet 143(2):125-32. 2003
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| 37 | SPARC
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| SPARC/osteonectin is a frequent target for aberrant methylation in pancreatic adenocarcinoma and a mediator of tumor-stromal interactions.
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| Sato N, Fukushima N, Maehara N, Matsubayashi H, Koopmann J, Su GH, Hruban RH, Goggins M.
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| Oncogene 22(32):5021-30. 2003
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| 38 | BGLAP, SPARC, DSPP
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| Investigation of osteocalcin, osteonectin, and dentin sialophosphoprotein in developing human teeth.
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| Papagerakis P, Berdal A, Mesbah M, Peuchmaur M, Malaval L, Nydegger J, Simmer J, Macdougall M.
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| Bone 30(2):377-85. 2002
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| 39 | SPARC
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| Localization of SPARC in developing, mature, and chronically injured human allograft kidneys.
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| Alpers CE, Hudkins KL, Segerer S, Sage EH, Pichler R, Couser WG, Johnson RJ, Bassuk JA.
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| Kidney Int 62(6):2073-86. 2002
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| 40 | SPARC
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| SPARC modulates cell growth, attachment and migration of U87 glioma cells on brain extracellular matrix proteins.
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| Rempel SA, Golembieski WA, Fisher JL, Maile M, Nakeff A.
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| J Neurooncol 53(2):149-60. 2001
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| 41 | SPARC
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| Involvement of SPARC in in vitro differentiation of skeletal myoblasts.
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| Cho WJ, Kim EJ, Lee SJ, Kim HD, Shin HJ, Lim WK.
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| Biochem Biophys Res Commun 271(3):630-4. 2000
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| 42 | SPARC
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| Osteonectin/SPARC is overexpressed in human hepatocellular carcinoma.
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| Le Bail B, Faouzi S, Boussarie L, Guirouilh J, Blanc JF, Carles J, Bioulac-Sage P, Balabaud C, Rosenbaum J.
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| J Pathol 189(1):46-52 1999
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| 43 | SPARC
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| SPARC/osteonectin induces matrix metalloproteinase 2 activation in human breast cancer cell lines.
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| Gilles C, et al.
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| Cancer Res 58 : 5529-5536. 1998
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| 44 | SPARC
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| The human osteonectin gene (OSN) has TaqI and MspI polymorphisms.
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| Naylor SL, et al.
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| Nucleic Acids Res 17 : 6753. 1989
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| 45 | SPARC
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| The human osteonectin gene on chromosome 5 is polymorphic.
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| Naylor SL, et al.
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| (HGM10) Cytogenet Cell Genet 51 : 1051. 1989
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| 46 | SPARC
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| Molecular analysis of the cDNA for human SPARC/Osteonectin/BM-40 : sequence, expression, and localization of the gene to chromosome 5q31-q33.
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| Swaroop A, et al.
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| Genomics 2 : 37-47. 1988
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| 47 | SPARC
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| Two RFLPs in the 5' end of the human osteonectin (ON) gene.
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| Schwartz RC, et al.
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| Nucleic Acids Res 16 : 9076. 1988
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| 48 | SPARC
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| Regional mapping of genes on mouse chromosome 11 and comparison to the homologous loci in man.
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| Mnke M, et al.
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| 7th Int Congr Hum Genet II : 605. 1986
|