| basic FUNCTION
| ligand activated protein-tyrosine kinase that utilizes autophosphorylation sites to regulate kinase activity and to control interactions with signaling proteins |
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disrupts cell adhesion by uncoupling adherens junction complexes from the cytoskeleton and promoting cadherin internalization through a Src-dependent mechanism and could contribute to invasive progression in epithelial cancers  |
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undergoes regulated intramembrane proteolysis, releasing the intracellular domain from the plasma membrane, enabling it to move to other compartments within the cell to participate in signaling |
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tyrosine kinase receptor that is absolutely required for macrophage differentiation and thus occupies a central role in hematopoiesis |
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CSF1R, through GAB2, utilizes different effectors at different stages of mononuclear phagocytes development to promote their expansion |
