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FLASH GENE
Symbol SP6 contributors: mct/npt - updated : 28-03-2014
HGNC name Sp6 transcription factor
HGNC id 14530
Location 17q21.32      Physical location : 45.922.279 - 45.933.240
Synonym name
  • Kruppel-like factor 14
  • epiprofin
  • Synonym symbol(s) EPFN, EPIPROFIN, KLF14, MGC119662, MGC119663, MGC119664, MGC119665
    DNA
    TYPE functioning gene
    STRUCTURE 10.96 kb     2 Exon(s)
    text structure
  • exon 1 containing a potential ATG translation initiator codon and an upstream TATAA box
  • exon 2 containing a second potential ATG start codon
  • MAPPING cloned Y linked N status provisional
    Physical map
    GOSR2 17q21 golgi SNAP receptor complex member 2 LOC388394 17 similar to RIKEN cDNA 2410012A13 LOC388395 17 similar to Hypothetical protein KIAA0563 LOC388396 17 similar to KIAA0563 protein LOC388397 17 LOC388397 CDC27 17q21.3 cell division cycle 27 MYL4 17q21.2 myosin, light polypeptide 4, alkali; atrial, embryonic ITGB3 17q21.31 integrin, beta 3 (platelet glycoprotein IIIa, antigen CD61) FLJ40342 17q21.32 hypothetical protein FLJ40342 NPEPPS 17q21.2-q21.32 aminopeptidase puromycin sensitive KPNB1 17q21.32 karyopherin (importin) beta 1 ProSAPiP2 17q21.32 ProSAPiP2 protein TBX21 17q21.3 T-box 21 OSBPL7 17q21.2 oxysterol binding protein-like 7 MRPL10 17q21.32 mitochondrial ribosomal protein L10 MGC16309 17q21.32 hypothetical gene MGC16309 Ses2 17q21.32 secernin 2 SP6 17q21.3-q22 Sp6 transcription factor LOC388398 17 LOC388398 SP2 17q21.3-q22 Sp2 transcription factor PNPO 17q21.32 pyridoxine-5'-phosphate oxidase MGC11242 17q21.32 hypothetical protein MGC11242 CDK5RAP3 17q21.2 CDK5 regulatory subunit associated protein 3 COPZ2 17q21.3 coatomer protein complex, subunit zeta 2 NFE2L1 17q21.3 nuclear factor (erythroid-derived 2)-like 1 CBX1 17q21.32 chromobox homolog 1 (HP1 beta homolog Drosophila ) SNX11 17q21.2 sorting nexin 11 SCAP1 17q21.32 src family associated phosphoprotein 1 HOXB1 17q21.3 homeo box B1 HOXB2 17q21.3 homeo box B2 HOXB3 17q21.3 homeo box B3 HOXB4 17q21.3 homeo box B4 HOXB5 17q21.3 homeo box B5 HOXB6 17q21.3 homeo box B6
    RNA
    TRANSCRIPTS type messenger
    text uses two promoters, generating two transcript variants which differ in their first exon (PMID: 17624655 )
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    2 - 3794 - 376 - Nakamura (2004)
    EXPRESSION
    Type restricted
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Digestivemouthtooth    Homo sapiens
    Nervousnerve    
    Reproductivefemale systemplacenta   
    Skin/Tegumentskin appendageshairfollicle   Homo sapiens
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    physiological period embryo
    Text
  • epithelium of developing teeth, hair follicles, and limb buds
  • expressed in the limb ectoderm
  • PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • maybe a putative N terminal proline-rich domain
  • a buttonhead (BTD) box CXCPXC, just N-terminal to the zinc fingers
  • 3 classical zinc finger DNA-binding domains consisting of a zinc atom tetrahedrally coordinated by 2 cysteines and 2 histidines (C2H2 motif)
  • three Sp-1-like zinc finger motifs at the C terminus
  • HOMOLOGY
    intraspecies homolog to SP2
    Homologene
    FAMILY
  • SP/XKLF transcriptions factor family
  • CATEGORY transcription factor
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,nucleus
    basic FUNCTION
  • highly cell- and tissue-specific nuclear protein expressed primarily by proliferating epithelial cells of teeth, hair follicles, and limbs that may function in the development of these tissues by regulating cell growth
  • having multiple functions for cell fate determination of the dental epithelium by regulating both proliferation and differentiation, preventing continuous tooth budding and generation
  • essential regulator for branching of tooth buds to form the proper number of teeth and for differentiation of the dental epithelium and mesenchyme
  • has multiple functions for cell fate determination of the dental epithelium by regulating both proliferation and differentiation, preventing continuous tooth budding and generation
  • very likely functions as a modulator of WNT signaling in the limb ectoderm
  • regulate cell proliferation in a cell-type-specific manner
  • CELLULAR PROCESS nucleotide, transcription
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA binding
    RNA
    small molecule other,
  • bind to GC-rich sequences and related GT and CACCC boxes
  • protein
  • follistatin gene is one of the SP6 target genes in ameloblasts, suggesting that SP6 promotes amelogenesis through inhibition of follistatin gene expression
  • BCL11B binds to the SP6 promoter, and regulates SP6 gene expression through direct binding to the SP6 second promoter region
  • cell & other
    REGULATION
    Other controlled by WNT/CTNNB signaling in the limb ectoderm
    regulation of SP6 protein stability is one of the crucial steps in amelogenesis
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS