Selected-GenAtlas references SOURCE GeneCards NCBI Gene Swiss-Prot Ensembl
HGNC UniGene Nucleotide OMIM UCSC
Home Page
FLASH GENE
Symbol SP6 contributors: mct/npt - updated : 28-03-2014
HGNC name Sp6 transcription factor
HGNC id 14530
EXPRESSION
Type restricted
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Digestivemouthtooth    Homo sapiens
Nervousnerve    
Reproductivefemale systemplacenta   
Skin/Tegumentskin appendageshairfollicle   Homo sapiens
cell lineage
cell lines
fluid/secretion
at STAGE
physiological period embryo
Text
  • epithelium of developing teeth, hair follicles, and limb buds
  • expressed in the limb ectoderm
  • PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • maybe a putative N terminal proline-rich domain
  • a buttonhead (BTD) box CXCPXC, just N-terminal to the zinc fingers
  • 3 classical zinc finger DNA-binding domains consisting of a zinc atom tetrahedrally coordinated by 2 cysteines and 2 histidines (C2H2 motif)
  • three Sp-1-like zinc finger motifs at the C terminus
  • HOMOLOGY
    intraspecies homolog to SP2
    Homologene
    FAMILY
  • SP/XKLF transcriptions factor family
  • CATEGORY transcription factor
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,nucleus
    basic FUNCTION
  • highly cell- and tissue-specific nuclear protein expressed primarily by proliferating epithelial cells of teeth, hair follicles, and limbs that may function in the development of these tissues by regulating cell growth
  • having multiple functions for cell fate determination of the dental epithelium by regulating both proliferation and differentiation, preventing continuous tooth budding and generation
  • essential regulator for branching of tooth buds to form the proper number of teeth and for differentiation of the dental epithelium and mesenchyme
  • has multiple functions for cell fate determination of the dental epithelium by regulating both proliferation and differentiation, preventing continuous tooth budding and generation
  • very likely functions as a modulator of WNT signaling in the limb ectoderm
  • regulate cell proliferation in a cell-type-specific manner
  • CELLULAR PROCESS nucleotide, transcription
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA binding
    RNA
    small molecule other,
  • bind to GC-rich sequences and related GT and CACCC boxes
  • protein
  • follistatin gene is one of the SP6 target genes in ameloblasts, suggesting that SP6 promotes amelogenesis through inhibition of follistatin gene expression
  • BCL11B binds to the SP6 promoter, and regulates SP6 gene expression through direct binding to the SP6 second promoter region
  • cell & other
    REGULATION
    Other controlled by WNT/CTNNB signaling in the limb ectoderm
    regulation of SP6 protein stability is one of the crucial steps in amelogenesis
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS