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FLASH GENE
Symbol SP6 contributors: mct/npt - updated : 28-03-2014
HGNC name Sp6 transcription factor
HGNC id 14530
DNA
TYPE functioning gene
STRUCTURE 10.96 kb     2 Exon(s)
text structure
  • exon 1 containing a potential ATG translation initiator codon and an upstream TATAA box
  • exon 2 containing a second potential ATG start codon
  • MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    text uses two promoters, generating two transcript variants which differ in their first exon (PMID: 17624655 )
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    2 - 3794 - 376 - Nakamura (2004)
    EXPRESSION
    Type restricted
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Digestivemouthtooth    Homo sapiens
    Nervousnerve    
    Reproductivefemale systemplacenta   
    Skin/Tegumentskin appendageshairfollicle   Homo sapiens
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    physiological period embryo
    Text
  • epithelium of developing teeth, hair follicles, and limb buds
  • expressed in the limb ectoderm
  • PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • maybe a putative N terminal proline-rich domain
  • a buttonhead (BTD) box CXCPXC, just N-terminal to the zinc fingers
  • 3 classical zinc finger DNA-binding domains consisting of a zinc atom tetrahedrally coordinated by 2 cysteines and 2 histidines (C2H2 motif)
  • three Sp-1-like zinc finger motifs at the C terminus
  • HOMOLOGY
    intraspecies homolog to SP2
    Homologene
    FAMILY
  • SP/XKLF transcriptions factor family
  • CATEGORY transcription factor
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,nucleus
    basic FUNCTION
  • highly cell- and tissue-specific nuclear protein expressed primarily by proliferating epithelial cells of teeth, hair follicles, and limbs that may function in the development of these tissues by regulating cell growth
  • having multiple functions for cell fate determination of the dental epithelium by regulating both proliferation and differentiation, preventing continuous tooth budding and generation
  • essential regulator for branching of tooth buds to form the proper number of teeth and for differentiation of the dental epithelium and mesenchyme
  • has multiple functions for cell fate determination of the dental epithelium by regulating both proliferation and differentiation, preventing continuous tooth budding and generation
  • very likely functions as a modulator of WNT signaling in the limb ectoderm
  • regulate cell proliferation in a cell-type-specific manner
  • CELLULAR PROCESS nucleotide, transcription
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA binding
    RNA
    small molecule other,
  • bind to GC-rich sequences and related GT and CACCC boxes
  • protein
  • follistatin gene is one of the SP6 target genes in ameloblasts, suggesting that SP6 promotes amelogenesis through inhibition of follistatin gene expression
  • BCL11B binds to the SP6 promoter, and regulates SP6 gene expression through direct binding to the SP6 second promoter region
  • cell & other
    REGULATION
    Other controlled by WNT/CTNNB signaling in the limb ectoderm
    regulation of SP6 protein stability is one of the crucial steps in amelogenesis
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS