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FLASH GENE

Symbol

SNTG1

contributors: npt - updated : 19-10-2005

HGNC name	syntrophin, gamma 1
HGNC id	13740

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

Location	8q11.2-q12      Physical location : 50.824.596 - 51.705.427
Synonym name	dystrophin associated protein A1
	syntrophin 4
Synonym symbol(s)	DAPA1G2, SYN4, G1SYN

DNA

TYPE	functioning gene
STRUCTURE	880.00 kb     19 Exon(s)

10 Kb 5' upstream gene genomic sequence study

MAPPING

cloned

Y

linked

N

status

provisional

RNA

TRANSCRIPTS	type	messenger

identification nb exons type bp product Protein kDa AA specific expression Year Pubmed variant 1 - splicing 1889 58 517 - Piluso variant 2 - splicing - - - - Piluso

EXPRESSION

Type

constitutive of

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Nervous brain diencephalon hypothalamus   predominantly   brain forebrain cerebral cortex   highly   brain hindbrain cerebellum cerebellar cortex     brain hindbrain cerebellum cerebellar nuclei     brain diencephalon thalamus       brain basal nuclei

tissue

System Tissue Tissue level 1 Tissue level 2 Level Pubmed Species Stage Rna symbol Nervous central       Nervous peripherous

cells

System Cell Pubmed Species Stage Rna symbol Nervous neuron

cell lineage

cell lines

fluid/secretion

at STAGE

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains	two pleckstrin homology (PH) domains
	a PDZ (PSD95/disc large/ZO1) domain

HOMOLOGY

interspecies	ortholog to murine Sntg1
	homolog to Drosophila Syn2
	homolog to C.elegans F27D9.8

Homologene

FAMILY

syntrophin family

CATEGORY

adaptor , structural protein

SUBCELLULAR LOCALIZATION	intracellular
	intracellular,cytoplasm
	intracellular,nucleus
text	mainly cytoplasmic and weakly nuclear

basic FUNCTION	organizing the subcellular localization of a variety of proteins
	participating in regulating the subcellular location of diacylglycerol kinase-zeta to ensure that diacylglycerol is rapidly inactivated following receptor activation
	linking various receptors to the actin cytoskeleton and the dystrophin glycoprotein complex

CELLULAR PROCESS

cell communication

PHYSIOLOGICAL PROCESS

PATHWAY

metabolism

signaling

signal transduction

intracellular signaling cascade

a component

dystrophin complex

INTERACTION

DNA

RNA

small molecule

protein	binding to the C terminal region of dystrophin and related proteins (DMD, DTNA and DTNB)
	binding to DGKZ and actin

cell & other

REGULATION

ASSOCIATED DISORDERS

ANIMAL & CELL MODELS