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FLASH GENE
Symbol SNTG1 contributors: npt - updated : 19-10-2005
HGNC name syntrophin, gamma 1
HGNC id 13740
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • two pleckstrin homology (PH) domains
  • a PDZ (PSD95/disc large/ZO1) domain
  • HOMOLOGY
    interspecies ortholog to murine Sntg1
    homolog to Drosophila Syn2
    homolog to C.elegans F27D9.8
    Homologene
    FAMILY
  • syntrophin family
  • CATEGORY adaptor , structural protein
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm
    intracellular,nucleus
    text mainly cytoplasmic and weakly nuclear
    basic FUNCTION
  • organizing the subcellular localization of a variety of proteins
  • participating in regulating the subcellular location of diacylglycerol kinase-zeta to ensure that diacylglycerol is rapidly inactivated following receptor activation
  • linking various receptors to the actin cytoskeleton and the dystrophin glycoprotein complex
  • CELLULAR PROCESS cell communication
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling signal transduction
    intracellular signaling cascade
    a component
  • dystrophin complex
  • INTERACTION
    DNA
    RNA
    small molecule
    protein
  • binding to the C terminal region of dystrophin and related proteins (DMD, DTNA and DTNB)
  • binding to DGKZ and actin
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS