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FLASH GENE
Symbol SNTG1 contributors: npt - updated : 19-10-2005
HGNC name syntrophin, gamma 1
HGNC id 13740
EXPRESSION
Type
constitutive of
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Nervousbraindiencephalonhypothalamus predominantly
 brainforebraincerebral cortex highly
 brainhindbraincerebellumcerebellar cortex 
 brainhindbraincerebellumcerebellar nuclei 
 braindiencephalonthalamus  
 brainbasal nuclei   
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Nervouscentral   
Nervousperipherous   
cells
SystemCellPubmedSpeciesStageRna symbol
Nervousneuron
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • two pleckstrin homology (PH) domains
  • a PDZ (PSD95/disc large/ZO1) domain
  • HOMOLOGY
    interspecies ortholog to murine Sntg1
    homolog to Drosophila Syn2
    homolog to C.elegans F27D9.8
    Homologene
    FAMILY
  • syntrophin family
  • CATEGORY adaptor , structural protein
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm
    intracellular,nucleus
    text mainly cytoplasmic and weakly nuclear
    basic FUNCTION
  • organizing the subcellular localization of a variety of proteins
  • participating in regulating the subcellular location of diacylglycerol kinase-zeta to ensure that diacylglycerol is rapidly inactivated following receptor activation
  • linking various receptors to the actin cytoskeleton and the dystrophin glycoprotein complex
  • CELLULAR PROCESS cell communication
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling signal transduction
    intracellular signaling cascade
    a component
  • dystrophin complex
  • INTERACTION
    DNA
    RNA
    small molecule
    protein
  • binding to the C terminal region of dystrophin and related proteins (DMD, DTNA and DTNB)
  • binding to DGKZ and actin
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS