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FLASH GENE
Symbol SNRPE contributors: mct - updated : 13-02-2013
HGNC name small nuclear ribonucleoprotein polypeptide E
HGNC id 11161
Corresponding disease
HTS4 hereditary hypotrichosis simplex 4
Location 1q32.1      Physical location : 203.830.739 - 203.840.278
Synonym name
  • spliceosomal protein E
  • Synonym symbol(s) SME, B-raf, Sm-E
    DNA
    TYPE functioning gene
    STRUCTURE 9.54 kb     5 Exon(s)
    Genomic sequence alignment details
    10 Kb 5' upstream gene genomic sequence study
    regulatory sequence cytosine-phosphate-guanine/HTF
    text structure
  • one copy of a GC box characteristic of a housekeeping promoter
  • CTTCCG hexamer sequence playing a role in transcriptional regulation
  • MAPPING cloned Y linked Y status confirmed
    Physical map
    LOC391152 1 similar to Tubulin alpha-2 chain (Alpha-tubulin 2) LOC388728 1 similar to alpha tubulin LOC391153 1 similar to actin RABIF 1q32-q41 RAB interacting factor C3IP1 1q32.1 kelch-like protein C3IP1 ADIPOR1 1p36.13-q41 adiponectin receptor 1 CYB5R1 1p36.13-q41 cytochrome b5 reductase 1 (B5R.1) LOC391154 1 similar to hypothetical protein 4933406M09 C1orf37 1q31.1 chromosome 1 open reading frame 37 PPFIA4 1q32.1 protein tyrosine phosphatase, receptor type, f polypeptide (PTPRF), interacting protein (liprin), alpha 4 MYOG 1q31-q41 myogenin (myogenic factor 4) ADORA1 1q32.1 adenosine A1 receptor MYBPH 1q32.1 myosin binding protein H CHI3L1 1q31-q32 chitinase 3-like 1 (cartilage glycoprotein-39) CHIT1 1q31-q32 chitinase 1 (chitotriosidase) LOC388729 1 LOC388729 BTG2 1q32 BTG family, member 2 FMOD 1q32.1 fibromodulin ATP2B4 1q32 ATPase, Ca++ transporting, plasma membrane 4 MGC5457 1q32.1 hypothetical protein MGC5457 LAX 1q32.1 hypothetical protein FLJ20340 KIAA0663 1q32.1 hypothetical protein FLJ20340 SNRPE 1q32 small nuclear ribonucleoprotein polypeptide E LOC391155 1 similar to KRT8 protein FLJ40343 1q32.1 hypothetical protein FLJ40343 SOX13 1q31.3-q32.1 SRY (sex determining region Y)-box 13 FLJ10761 1q32.1 putative ethanolamine kinase REN 1q32 renin KISS1 1q32 KiSS-1 metastasis-suppressor FLJ42654 1q32.1 FLJ42654 protein PEPP3 1q32.1 phosphoinositol 3-phosphate-binding protein-3 PPP1R15B 1q32.1 protein phosphatase 1, regulatory (inhibitor) subunit 15B PIK3C2B 1q32 phosphoinositide-3-kinase, class 2, beta polypeptide MDM4 1q32 Mdm4, transformed 3T3 cell double minute 4, p53 binding protein (mouse) GAC1
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    5 - 1593 - 92 - 2013 23246290
    EXPRESSION
    Type widely
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Cardiovascularheart   moderately
    Nervousbrain   moderately
    Reproductivemale systemprostate  highly
    Skin/Tegumentskin     Homo sapiensAdult
     skin appendageshairfollicle   Homo sapiensAdult
    Urinarykidney   moderately
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Blood / Hematopoieticbone marrow   
    Connectivebone   
    Muscularstriatumskeletal  
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES basic
    STRUCTURE
    motifs/domains
    conjugated RiboP
    HOMOLOGY
    interspecies ortholog to murine Snrpe
    ortholog to Drosophila Cg18591
    ortholog to C.elegans Y49e10.15
    Homologene
    FAMILY SNRNP SM proteins family
    CATEGORY RNA associated
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,cytosolic
    intracellular,nucleus
    basic FUNCTION
  • downstream effector of E2F1 in TP53-deficient human carcinoma cells
  • its activity was not associated with enhanced expression of other spliceosome components such as U1 SnRNP70, suggesting that the growth inhibitory effect of SmE is distinct from its pre-mRNA splicing function
  • core protein of U snRNPs, the key factors of the pre-mRNA processing spliceosome
  • core splicing factor that is required in all nucleated cells of the body for pre-mRNA maturation
  • CELLULAR PROCESS nucleotide, RNA splicing
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component component of the U1, U2, U4/U6 and U5 SnRNPs spliceosomal complex (spliceosome)
    INTERACTION
    DNA
    RNA binding Sn RNA
    small molecule
    protein
  • regulation of AR expression by SNRPE is essential for cell proliferation and progression of high-grade prostate carcinoma
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s) HTS4
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --over  
    in high-grade prostate carcinoma cells compared with normal prostatic epithelial cells
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    SystemTypeDisorderPubmed
    cancerreproductiveprostate
    may be a novel molecular target for cancer drugs
    ANIMAL & CELL MODELS