Selected-GenAtlas references SOURCE GeneCards NCBI Gene Swiss-Prot Ensembl
HGNC UniGene Nucleotide OMIM UCSC
Home Page
FLASH GENE
Symbol SNRPE contributors: mct - updated : 13-02-2013
HGNC name small nuclear ribonucleoprotein polypeptide E
HGNC id 11161
DNA
TYPE functioning gene
STRUCTURE 9.54 kb     5 Exon(s)
Genomic sequence alignment details
10 Kb 5' upstream gene genomic sequence study
regulatory sequence cytosine-phosphate-guanine/HTF
text structure
  • one copy of a GC box characteristic of a housekeeping promoter
  • CTTCCG hexamer sequence playing a role in transcriptional regulation
  • MAPPING cloned Y linked Y status confirmed
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    5 - 1593 - 92 - 2013 23246290
    EXPRESSION
    Type widely
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Cardiovascularheart   moderately
    Nervousbrain   moderately
    Reproductivemale systemprostate  highly
    Skin/Tegumentskin     Homo sapiensAdult
     skin appendageshairfollicle   Homo sapiensAdult
    Urinarykidney   moderately
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Blood / Hematopoieticbone marrow   
    Connectivebone   
    Muscularstriatumskeletal  
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES basic
    STRUCTURE
    motifs/domains
    conjugated RiboP
    HOMOLOGY
    interspecies ortholog to murine Snrpe
    ortholog to Drosophila Cg18591
    ortholog to C.elegans Y49e10.15
    Homologene
    FAMILY SNRNP SM proteins family
    CATEGORY RNA associated
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,cytosolic
    intracellular,nucleus
    basic FUNCTION
  • downstream effector of E2F1 in TP53-deficient human carcinoma cells
  • its activity was not associated with enhanced expression of other spliceosome components such as U1 SnRNP70, suggesting that the growth inhibitory effect of SmE is distinct from its pre-mRNA splicing function
  • core protein of U snRNPs, the key factors of the pre-mRNA processing spliceosome
  • core splicing factor that is required in all nucleated cells of the body for pre-mRNA maturation
  • CELLULAR PROCESS nucleotide, RNA splicing
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component component of the U1, U2, U4/U6 and U5 SnRNPs spliceosomal complex (spliceosome)
    INTERACTION
    DNA
    RNA binding Sn RNA
    small molecule
    protein
  • regulation of AR expression by SNRPE is essential for cell proliferation and progression of high-grade prostate carcinoma
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s) HTS4
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --over  
    in high-grade prostate carcinoma cells compared with normal prostatic epithelial cells
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    SystemTypeDisorderPubmed
    cancerreproductiveprostate
    may be a novel molecular target for cancer drugs
    ANIMAL & CELL MODELS