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FLASH GENE
Symbol SNRPE contributors: mct - updated : 13-02-2013
HGNC name small nuclear ribonucleoprotein polypeptide E
HGNC id 11161
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
5 - 1593 - 92 - 2013 23246290
EXPRESSION
Type widely
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Cardiovascularheart   moderately
Nervousbrain   moderately
Reproductivemale systemprostate  highly
Skin/Tegumentskin     Homo sapiensAdult
 skin appendageshairfollicle   Homo sapiensAdult
Urinarykidney   moderately
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Blood / Hematopoieticbone marrow   
Connectivebone   
Muscularstriatumskeletal  
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES basic
STRUCTURE
motifs/domains
conjugated RiboP
HOMOLOGY
interspecies ortholog to murine Snrpe
ortholog to Drosophila Cg18591
ortholog to C.elegans Y49e10.15
Homologene
FAMILY SNRNP SM proteins family
CATEGORY RNA associated
SUBCELLULAR LOCALIZATION     intracellular
intracellular,cytoplasm,cytosolic
intracellular,nucleus
basic FUNCTION
  • downstream effector of E2F1 in TP53-deficient human carcinoma cells
  • its activity was not associated with enhanced expression of other spliceosome components such as U1 SnRNP70, suggesting that the growth inhibitory effect of SmE is distinct from its pre-mRNA splicing function
  • core protein of U snRNPs, the key factors of the pre-mRNA processing spliceosome
  • core splicing factor that is required in all nucleated cells of the body for pre-mRNA maturation
  • CELLULAR PROCESS nucleotide, RNA splicing
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component component of the U1, U2, U4/U6 and U5 SnRNPs spliceosomal complex (spliceosome)
    INTERACTION
    DNA
    RNA binding Sn RNA
    small molecule
    protein
  • regulation of AR expression by SNRPE is essential for cell proliferation and progression of high-grade prostate carcinoma
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s) HTS4
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --over  
    in high-grade prostate carcinoma cells compared with normal prostatic epithelial cells
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    SystemTypeDisorderPubmed
    cancerreproductiveprostate
    may be a novel molecular target for cancer drugs
    ANIMAL & CELL MODELS