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FLASH GENE

Symbol

SMOC2

contributors: shn/pgu - updated : 17-01-2010

HGNC name	SPARC related modular calcium binding 2
HGNC id	20323

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

Corresponding disease	OLD2 oligodontia 2
Location	6q27      Physical location : 168.841.830 - 169.068.673
Synonym name	smooth muscle associated protein 2
	secreted modular calcium-binding protein 2
	SPARC-Related Modular Calcium Binding Protein-2
	thyroglobulin type-1 repeat containing protein
Synonym symbol(s)	SMOC-2, MST117, MSTP117, MSTP140, bA37D8.1, bA270C4A.1, dJ421D16.1, RP11-270C4__A.1

DNA

TYPE	functioning gene
STRUCTURE	226.84 kb     13 Exon(s)

10 Kb 5' upstream gene genomic sequence study

text structure	Smoc2 promoter contains two consensus putative Ahr-binding sites
	contains consensus Ahr/ARNT-binding sites

MAPPING

cloned

Y

linked

N

status

provisional

Map	cen - D6S1697 - D6S503 - SMOC2 - D6S281 - D6S1693 - qter

RNA

TRANSCRIPTS	type	messenger

text	has numerous splice variants, all of which share the C-terminal region, which includes two calcium-binding domains (PMID: 22152679)

identification nb exons type bp product Protein kDa AA specific expression Year Pubmed NM_001166412 13 splicing 3117 NP_001159884 - 446 - - NM_022138 13 splicing 3150 NP_071421 - 457 - -

EXPRESSION

Type

widely

expressed in

(based on citations)

organ(s)

System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Cardiovascular heart       highly Digestive intestine large intestine colon   moderately   intestine       highly   liver       lowly   salivary gland       moderately   stomach       highly Endocrine adrenal gland       moderately   pancreas       lowly   thyroid       highly Lymphoid/Immune thymus       moderately Nervous brain basal nuclei putamen   moderately   brain midbrain substantia nigra   lowly   brain hindbrain medulla oblongata   lowly   brain forebrain cerebral cortex   lowly   brain forebrain cerebral lobe occipital lobe lowly   brain limbic system hippocampus   lowly   brain diencephalon amygdala   lowly   brain basal nuclei caudate nucleus   moderately   brain forebrain cerebral lobe temporal lobe lowly   spinal cord       moderately Reproductive female system breast     highly   female system uterus     moderately   female system ovary     highly   female system placenta     moderately   male system prostate     moderately   male system testis     highly Respiratory lung       lowly   respiratory tract trachea     highly Urinary bladder       specific   kidney       moderately

tissue

System Tissue Tissue level 1 Tissue level 2 Level Pubmed Species Stage Rna symbol Blood / hematopoietic bone marrow     moderately

cell lineage

cell lines

fluid/secretion

at STAGE

Text	expressed in fetal testicular Leydig cells (steroid producing cells) and in the primordial reproductive tract

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains	a Kazal domain
	two thyroglobulin-like (TY) domains
	an follistatin (FS) domain
	a putative signal peptide
	C-terminal region including two two EF-hand calcium-binding domains

conjugated

GlycoP

HOMOLOGY

interspecies	ortholog to Smoc2, Mus musculus
	ortholog to smoc2, Danio rerio
	ortholog to Smoc2, Rattus norvegicus
	ortholog to SMOC2, Pan troglodytes

Homologene

FAMILY

matricellular proteins of SPARC family (secreted protein acidic and rich in cysteine/osteonectin/BM-40)

CATEGORY

regulatory

SUBCELLULAR LOCALIZATION	extracellular
text	matricellular protein

basic FUNCTION	might be involved in the progression of atherosclerosis in aorta
	angiogenic factor that can modulate angiogenic growth factor activity and angiogenesis
	potentiates responses to mitogenic and angiogenic factors including FGF and VEGF
	might associated with pulmonary function by playing an important role in the determination of FEV (ETS oncogene family) and FVC
	promotes keratinocyte attachment and migration and acts as a regulator of cell-matrix interactions
	a role for Smoc-2 in growth control, activation of Integrin-Linked Kinase (ILK) and cyclin D1 expression
	a role in cell cycle by maintaining ILK activity during G1 and involved in mediating the mitogenic and angiogenic
	effects of growth factors such as VEGF, PDGF, and FGF
	exhibits pro-angiogenic properties and stimulates cell cycle progression via integrin-linked kinase
	a novel transcriptional target of activated Aryl-hydrocarbon receptor (Ahr), has a possible role in embryonic gonad development
	with SMOC1 are matricellular proteins thought to influence growth factor signaling, migration, proliferation, and angiogenesis
	may mediate intercellular signaling and cell type-specific differentiation during gonad and reproductive tract development
	regulate interactions between cells and the extracellular matrix
	potential role in linking the extracellular matrix with the intracellular effector ILK
	particularly important for dental development but does not play a major role in eye and limb development

CELLULAR PROCESS	cell cycle

PHYSIOLOGICAL PROCESS

PATHWAY

metabolism

signaling

a component

INTERACTION

DNA

RNA

small molecule	metal binding,
	Ca2+ binding

protein	interact with integrins and contributes to cell-cycle progression by maintaining integrin-linked kinase (ILK) activity during the G1 phase of the cell cycle
	connection between the hyper-activation of the small GTPase RAN and the matricellular protein SMOC2 that has important consequences for oncogenic transformation

cell & other

REGULATION

repressed by

Aryl-hydrocarbon receptor in vitro and in vivo

Other

calcium-dependent conformation

ASSOCIATED DISORDERS

corresponding disease(s)

OLD2

Susceptibility

Variant & Polymorphism

Candidate gene

Marker

Therapy target

ANIMAL & CELL MODELS