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FLASH GENE
Symbol SMOC2 contributors: shn/pgu - updated : 17-01-2010
HGNC name SPARC related modular calcium binding 2
HGNC id 20323
Corresponding disease
OLD2 oligodontia 2
Location 6q27      Physical location : 168.841.830 - 169.068.673
Synonym name
  • smooth muscle associated protein 2
  • secreted modular calcium-binding protein 2
  • SPARC-Related Modular Calcium Binding Protein-2
  • thyroglobulin type-1 repeat containing protein
  • Synonym symbol(s) SMOC-2, MST117, MSTP117, MSTP140, bA37D8.1, bA270C4A.1, dJ421D16.1, RP11-270C4__A.1
    DNA
    TYPE functioning gene
    STRUCTURE 226.84 kb     13 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    text structure Smoc2 promoter contains two consensus putative Ahr-binding sites
    contains consensus Ahr/ARNT-binding sites
    MAPPING cloned Y linked N status provisional
    Map cen - D6S1697 - D6S503 - SMOC2 - D6S281 - D6S1693 - qter
    RNA
    TRANSCRIPTS type messenger
    text
  • has numerous splice variants, all of which share the C-terminal region, which includes two calcium-binding domains (PMID: 22152679)
  • identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    13 splicing 3117 - 446 - -
    13 splicing 3150 - 457 - -
    EXPRESSION
    Type widely
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Cardiovascularheart   highly
    Digestiveintestinelarge intestinecolon moderately
     intestine   highly
     liver   lowly
     salivary gland   moderately
     stomach   highly
    Endocrineadrenal gland   moderately
     pancreas   lowly
     thyroid   highly
    Lymphoid/Immunethymus   moderately
    Nervousbrainbasal nucleiputamen moderately
     brainmidbrainsubstantia nigra lowly
     brainhindbrainmedulla oblongata lowly
     brainforebraincerebral cortex lowly
     brainforebraincerebral lobeoccipital lobelowly
     brainlimbic systemhippocampus lowly
     braindiencephalonamygdala lowly
     brainbasal nucleicaudate nucleus moderately
     brainforebraincerebral lobetemporal lobelowly
     spinal cord   moderately
    Reproductivefemale systembreast  highly
     female systemuterus  moderately
     female systemovary  highly
     female systemplacenta  moderately
     male systemprostate  moderately
     male systemtestis  highly
    Respiratorylung   lowly
     respiratory tracttrachea  highly
    Urinarybladder   specific
     kidney   moderately
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Blood / hematopoieticbone marrow  moderately
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    Text expressed in fetal testicular Leydig cells (steroid producing cells) and in the primordial reproductive tract
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • a Kazal domain
  • two thyroglobulin-like (TY) domains
  • an follistatin (FS) domain
  • a putative signal peptide
  • C-terminal region including two two EF-hand calcium-binding domains
  • conjugated GlycoP
    HOMOLOGY
    interspecies ortholog to Smoc2, Mus musculus
    ortholog to smoc2, Danio rerio
    ortholog to Smoc2, Rattus norvegicus
    ortholog to SMOC2, Pan troglodytes
    Homologene
    FAMILY
  • matricellular proteins of SPARC family (secreted protein acidic and rich in cysteine/osteonectin/BM-40)
  • CATEGORY regulatory
    SUBCELLULAR LOCALIZATION extracellular
    text matricellular protein
    basic FUNCTION
  • might be involved in the progression of atherosclerosis in aorta
  • angiogenic factor that can modulate angiogenic growth factor activity and angiogenesis
  • potentiates responses to mitogenic and angiogenic factors including FGF and VEGF
  • might associated with pulmonary function by playing an important role in the determination of FEV (ETS oncogene family) and FVC
  • promotes keratinocyte attachment and migration and acts as a regulator of cell-matrix interactions
  • a role for Smoc-2 in growth control, activation of Integrin-Linked Kinase (ILK) and cyclin D1 expression
  • a role in cell cycle by maintaining ILK activity during G1 and involved in mediating the mitogenic and angiogenic
  • effects of growth factors such as VEGF, PDGF, and FGF
  • exhibits pro-angiogenic properties and stimulates cell cycle progression via integrin-linked kinase
  • a novel transcriptional target of activated Aryl-hydrocarbon receptor (Ahr), has a possible role in embryonic gonad development
  • with SMOC1 are matricellular proteins thought to influence growth factor signaling, migration, proliferation, and angiogenesis
  • may mediate intercellular signaling and cell type-specific differentiation during gonad and reproductive tract development
  • regulate interactions between cells and the extracellular matrix
  • potential role in linking the extracellular matrix with the intracellular effector ILK
  • particularly important for dental development but does not play a major role in eye and limb development
  • CELLULAR PROCESS cell cycle
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule metal binding,
  • Ca2+ binding
  • protein
  • interact with integrins and contributes to cell-cycle progression by maintaining integrin-linked kinase (ILK) activity during the G1 phase of the cell cycle
  • connection between the hyper-activation of the small GTPase RAN and the matricellular protein SMOC2 that has important consequences for oncogenic transformation
  • cell & other
    REGULATION
    repressed by Aryl-hydrocarbon receptor in vitro and in vivo
    Other calcium-dependent conformation
    ASSOCIATED DISORDERS
    corresponding disease(s) OLD2
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS