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FLASH GENE
Symbol SMOC2 contributors: shn/pgu - updated : 17-01-2010
HGNC name SPARC related modular calcium binding 2
HGNC id 20323
EXPRESSION
Type widely
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Cardiovascularheart   highly
Digestiveintestinelarge intestinecolon moderately
 intestine   highly
 liver   lowly
 salivary gland   moderately
 stomach   highly
Endocrineadrenal gland   moderately
 pancreas   lowly
 thyroid   highly
Lymphoid/Immunethymus   moderately
Nervousbrainbasal nucleiputamen moderately
 brainmidbrainsubstantia nigra lowly
 brainhindbrainmedulla oblongata lowly
 brainforebraincerebral cortex lowly
 brainforebraincerebral lobeoccipital lobelowly
 brainlimbic systemhippocampus lowly
 braindiencephalonamygdala lowly
 brainbasal nucleicaudate nucleus moderately
 brainforebraincerebral lobetemporal lobelowly
 spinal cord   moderately
Reproductivefemale systembreast  highly
 female systemuterus  moderately
 female systemovary  highly
 female systemplacenta  moderately
 male systemprostate  moderately
 male systemtestis  highly
Respiratorylung   lowly
 respiratory tracttrachea  highly
Urinarybladder   specific
 kidney   moderately
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Blood / hematopoieticbone marrow  moderately
cell lineage
cell lines
fluid/secretion
at STAGE
Text expressed in fetal testicular Leydig cells (steroid producing cells) and in the primordial reproductive tract
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • a Kazal domain
  • two thyroglobulin-like (TY) domains
  • an follistatin (FS) domain
  • a putative signal peptide
  • C-terminal region including two two EF-hand calcium-binding domains
  • conjugated GlycoP
    HOMOLOGY
    interspecies ortholog to Smoc2, Mus musculus
    ortholog to smoc2, Danio rerio
    ortholog to Smoc2, Rattus norvegicus
    ortholog to SMOC2, Pan troglodytes
    Homologene
    FAMILY
  • matricellular proteins of SPARC family (secreted protein acidic and rich in cysteine/osteonectin/BM-40)
  • CATEGORY regulatory
    SUBCELLULAR LOCALIZATION extracellular
    text matricellular protein
    basic FUNCTION
  • might be involved in the progression of atherosclerosis in aorta
  • angiogenic factor that can modulate angiogenic growth factor activity and angiogenesis
  • potentiates responses to mitogenic and angiogenic factors including FGF and VEGF
  • might associated with pulmonary function by playing an important role in the determination of FEV (ETS oncogene family) and FVC
  • promotes keratinocyte attachment and migration and acts as a regulator of cell-matrix interactions
  • a role for Smoc-2 in growth control, activation of Integrin-Linked Kinase (ILK) and cyclin D1 expression
  • a role in cell cycle by maintaining ILK activity during G1 and involved in mediating the mitogenic and angiogenic
  • effects of growth factors such as VEGF, PDGF, and FGF
  • exhibits pro-angiogenic properties and stimulates cell cycle progression via integrin-linked kinase
  • a novel transcriptional target of activated Aryl-hydrocarbon receptor (Ahr), has a possible role in embryonic gonad development
  • with SMOC1 are matricellular proteins thought to influence growth factor signaling, migration, proliferation, and angiogenesis
  • may mediate intercellular signaling and cell type-specific differentiation during gonad and reproductive tract development
  • regulate interactions between cells and the extracellular matrix
  • potential role in linking the extracellular matrix with the intracellular effector ILK
  • particularly important for dental development but does not play a major role in eye and limb development
  • CELLULAR PROCESS cell cycle
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule metal binding,
  • Ca2+ binding
  • protein
  • interact with integrins and contributes to cell-cycle progression by maintaining integrin-linked kinase (ILK) activity during the G1 phase of the cell cycle
  • connection between the hyper-activation of the small GTPase RAN and the matricellular protein SMOC2 that has important consequences for oncogenic transformation
  • cell & other
    REGULATION
    repressed by Aryl-hydrocarbon receptor in vitro and in vivo
    Other calcium-dependent conformation
    ASSOCIATED DISORDERS
    corresponding disease(s) OLD2
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS