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FLASH GENE

Symbol

SLC5A12

contributors: mct/npt - updated : 29-03-2010

HGNC name	solute carrier family 5 (sodium/glucose cotransporter), member 12
HGNC id	28750

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

Location	11p14.2      Physical location : 26.688.565 - 26.743.574
Synonym name	electroneutral sodium monocarboxylate cotransporter
	sodium-iodide related cotransporter
	sodium-iodide related cotransporter
	low-affinity sodium-lactate cotransporter3
Synonym symbol(s)	MGC52019, SMCT2, DKFZp564G223

DNA

TYPE	functioning gene
STRUCTURE	55.01 kb     15 Exon(s)

MAPPING

cloned

Y

linked

N

status

provisional

RNA

TRANSCRIPTS	type	messenger

identification nb exons type bp product Protein kDa AA specific expression Year Pubmed NM_178498 15 - 6253 NP_848593 - 618 - Gopel (2007) variant 2 - - 2315 isoform 2 - 396 - -

EXPRESSION

Type	restricted

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Digestive intestine small intestine       Nervous brain         Urinary kidney tubule convoluted tubule proximal tubule specific Visual eye retina     highly

tissue

System Tissue Tissue level 1 Tissue level 2 Level Pubmed Species Stage Rna symbol Muscular striatum skeletal

cells

System Cell Pubmed Species Stage Rna symbol Nervous astrocyte Visual Muller cell

cell lineage

cell lines

fluid/secretion

at STAGE

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains

HOMOLOGY

interspecies

ortholog to murine Slc5a12

Homologene

FAMILY

sodium:solute symporter (SSF) family

CATEGORY

transport carrier

SUBCELLULAR LOCALIZATION	plasma membrane
text	with SLC5A8 are expressed in the apical membrane of the tubular cell (Gopal 2007)
	localized to the apical membrane of epithelial cells lining the intestinal tract and proximal tubule (Ganapathy 2008)

basic FUNCTION	acting as a sodium/glucose cotransporter
	mediates Na(+)-coupled transport of lactate, pyruvate and nicotinate (Gopal 2007)
	low-affinity transporter initiating lactate absorption in the early parts of the proximal tubule (Gopal 2007)
	play a differential role in monocarboxylate transport in the retina in a cell type-specific manner
	in the kidney is likely to mediate the reabsorption of lactate and in the intestinal tract (in the proximal parts), mediate the absorption of diet-derived short-chain monocarboxylates

CELLULAR PROCESS

PHYSIOLOGICAL PROCESS

PATHWAY

metabolism

signaling

a component

INTERACTION

DNA

RNA

small molecule

protein

cell & other

REGULATION

ASSOCIATED DISORDERS

ANIMAL & CELL MODELS