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FLASH GENE
Symbol SLC5A12 contributors: mct/npt - updated : 29-03-2010
HGNC name solute carrier family 5 (sodium/glucose cotransporter), member 12
HGNC id 28750
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
15 - 6253 - 618 - Gopel (2007)
- - 2315 - 396 - -
EXPRESSION
Type restricted
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Digestiveintestinesmall intestine   
Nervousbrain    
Urinarykidneytubuleconvoluted tubuleproximal tubulespecific
Visualeyeretina  highly
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Muscularstriatumskeletal  
cells
SystemCellPubmedSpeciesStageRna symbol
Nervousastrocyte
VisualMuller cell
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
HOMOLOGY
interspecies ortholog to murine Slc5a12
Homologene
FAMILY
  • sodium:solute symporter (SSF) family
  • CATEGORY transport carrier
    SUBCELLULAR LOCALIZATION     plasma membrane
    text
  • with SLC5A8 are expressed in the apical membrane of the tubular cell (Gopal 2007)
  • localized to the apical membrane of epithelial cells lining the intestinal tract and proximal tubule (Ganapathy 2008)
  • basic FUNCTION
  • acting as a sodium/glucose cotransporter
  • mediates Na(+)-coupled transport of lactate, pyruvate and nicotinate (Gopal 2007)
  • low-affinity transporter initiating lactate absorption in the early parts of the proximal tubule (Gopal 2007)
  • play a differential role in monocarboxylate transport in the retina in a cell type-specific manner
  • in the kidney is likely to mediate the reabsorption of lactate and in the intestinal tract (in the proximal parts), mediate the absorption of diet-derived short-chain monocarboxylates
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS