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FLASH GENE
Symbol SLC5A12 contributors: mct/npt - updated : 29-03-2010
HGNC name solute carrier family 5 (sodium/glucose cotransporter), member 12
HGNC id 28750
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
HOMOLOGY
interspecies ortholog to murine Slc5a12
Homologene
FAMILY
  • sodium:solute symporter (SSF) family
    • CATEGORY transport carrier
    SUBCELLULAR LOCALIZATION     plasma membrane
    text
  • with SLC5A8 are expressed in the apical membrane of the tubular cell (Gopal 2007)
  • localized to the apical membrane of epithelial cells lining the intestinal tract and proximal tubule (Ganapathy 2008)
    • basic FUNCTION
  • acting as a sodium/glucose cotransporter
  • mediates Na(+)-coupled transport of lactate, pyruvate and nicotinate (Gopal 2007)
  • low-affinity transporter initiating lactate absorption in the early parts of the proximal tubule (Gopal 2007)
  • play a differential role in monocarboxylate transport in the retina in a cell type-specific manner
  • in the kidney is likely to mediate the reabsorption of lactate and in the intestinal tract (in the proximal parts), mediate the absorption of diet-derived short-chain monocarboxylates
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS