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FLASH GENE
Symbol SLC3A2 contributors: mct/npt - updated : 18-02-2016
HGNC name solute carrier family 3 (activators of dibasic and neutral amino acid transport), member 2
HGNC id 11026
Location 11q12.3      Physical location : 62.623.517 - 62.656.352
Synonym name
  • 4F2 cell-surface antigen heavy chain
  • CD98 heavy chainby monoclonal antibodies 4F
  • antigen defined by monoclonal antibody 4F2, heavy chain
  • antigen identified 2, TRA1.10, TROP4, and T43
  • CD98 heavy chain
  • monoclonal antibody 44D7
  • 4F2 cell-surface antigen heavy chain
  • lymphocyte activation antigen 4F2 large subunit
  • Synonym symbol(s) MIC8, S2, CD98, 4F2HC, MDU1, 4FZHC, CD98HC, NACAE, 4T2HC, 4F2, CD98HC
    DNA
    TYPE functioning gene
    STRUCTURE 32.84 kb     13 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status confirmed
    Physical map
    MGC5395 11q12.2 hypothetical protein MGC5395 EEF1G 11q13.2 eukaryotic translation elongation factor 1 gamma FLJ22347 11q12.2 hypothetical protein FLJ22347 MTA2 11q12-q13.1 metastais-associated gene family, member 2 FLJ35827 11q12.3 hypothetical protein FLJ35827 ROM1 11q13.1 retinal outer segment membrane protein 1 B3GAT3 11q12.2 beta-1,3-glucuronyltransferase 3 (glucuronosyltransferase I) G2AN 11q12.3 alpha glucosidase II alpha subunit KIAA1698 11q12.3 KIAA1698 protein MGC2477 11q12.3 hypothetical protein MGC2477 LOC51035 11q12.3 ORF LOC221091 11q12.3 similar to hypothetical protein BSCL2 11q12.q13.5 Bernardinelli-Seip congenital lipodystrophy 2 (seipin) GNG3 11p11 guanine nucleotide binding protein (G protein), gamma 3 DKFZp762N1910 11q12.3 hypothetical protein DKFZp762N1910 MGC29649 11q12.3 hypothetical protein MGC29649 ZBTB3 11q12.3 zinc finger and BTB domain containing 3 POLR2G 11q13.1 polymerase (RNA) II (DNA directed) polypeptide G TAF6L 11q13.1 TAF6-like RNA polymerase II, p300/CBP-associated factor (PCAF)-associated factor, 65kDa LOC387617 11 hypothetical gene supported by NM_018336 LOC374395 11q12.3 similar to RIKEN cDNA 1810059G22 NXF1 11q12-q13 nuclear RNA export factor 1 STX5A 11cen-q12.1 syntaxin 5A FLJ10439 11q12.3 hypothetical protein FLJ10439 SLC3A2 11q12-q22 solute carrier family 3 (activators of dibasic and neutral amino acid transport), member 2 CHRM1 11q12-q13 cholinergic receptor, muscarinic 1 SLC22A6 11q13.1-q13.2 solute carrier family 22 (organic anion transporter), member 6 SLC22A8 11q11.7 solute carrier family 22 (organic anion transporter), member 8 LOC390207 11 similar to Tubulin alpha-4 chain (Alpha-tubulin 4) LOC390208 11 similar to ribosomal protein L29
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    13 - 2408 - 661 - 2006 16344560
    12 - 2318 - 631 - 2006 16344560
    12 - 2315 - 630 - 2006 16344560
    11 - 2222 - 599 - 2006 16344560
    10 - 2129 - 568 - 2006 16344560
    - - 1997 57 529 - 2006 16344560
    EXPRESSION
    Type ubiquitous
       expressed in (based on citations)
    organ(s)
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    physiological period pregnancy
    Text placenta, in developing placental trophoblast
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • a transmembrane domain necessary and sufficient for integrin association in cells
  • potential phosphorylation sites in its extracellular C-terminal tail
  • conjugated GlycoP
    mono polymer heteromer , dimer
    HOMOLOGY
    Homologene
    FAMILY
  • solute carrier family 3
  • SLC3A transporter family
  • CATEGORY antigen , transport carrier
    SUBCELLULAR LOCALIZATION extracellular
        plasma membrane
        intracellular
    intracellular,cytoplasm
    intracellular,nucleus
    text
  • membrane protein, as an important component of the matrix assembly machinery
  • is a disulfide-linked heterodimeric type II transmembrane glycoprotein
  • basic FUNCTION
  • involved in T cell activation and in normal and neoplastic cell growth
  • can control the capacity of cells to assemble an Fibronectin matrix, a process important in development, wound healing, and tumorigenesis
  • may cooperate with other cytoplasmic domain binding proteins to modulate integrin functions and into the evolution of integrin signaling
  • involved in the export of the diamine putrescine and monoacetylated spermidine
  • extracellular signaling through ecto-protein kinases (EPKs) might lead to ecto-phosphorylation of SLC3A2 and influence its multiple functions, including its role in cell-cell interactions
  • mediating notoriously invasive activity of extravillous trophoblast by promoting alpha(v)beta(3) integrin-dependent signals
  • importance of SLC2A3 in vascular smooth muscle cells (VSMCs) proliferation and survival
  • is likely involved in integrin trafficking and by consequence, in keratinocyte adhesion and differentiation
  • play an important role in the activation and functions of macrophages
  • in colitis, regulates the expansion of autoimmune CD4(+) T cells in addition to controlling nTregs functions
  • SLC3A2/BSG complex significantly contributes to poor prognosis of NSCLC patients through promoting cell proliferation via the PI3K/Akt pathway
  • contributes to carcinogenesis by amplifying a positive feedback loop, which increases both extracellular matrix stiffness and resulting cellular responses
  • CD99 and SLC3A2 oppositely regulate ITGB1 signaling
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
  • heterodimerizing with 4F2HC chain such as SLC7A5, SLC7A7 and others
  • disulfide-linked heterodimer of a glycosylated heavy chain and a nonglycosylated light chain
  • component of a transporter capable of exporting the diamine putrescine
  • BSG an SLC3A2 form a complex on the cell plasma membrane of several cancers
  • heavy chain component of the dimeric transmembrane glycoprotein CD98, which comprises the large neutral amino acid transporter LAT1 (SLC7A5) in cells
  • is a disulfide-linked 125-kDa heterodimeric type II transmembrane glycoprotein
  • INTERACTION
    DNA
    RNA
    small molecule
    protein
  • interaction with ITGB1 is required for transformation
  • interacting with FAM57A and GGTL3
  • SLC3A2 and SAT1 may form a complex at the plasma membrane (may interact with SLC3A2 to couple acetylation and export of the longer chain polyamines, spermidine and spermine)
  • interaction with SAT1 (these proteins may be facilitate excretion of acetylated polyamines)
  • MARCH8 expression completely shifted the trafficking of CD44 and SLC3A2 proteins away from recycling tubules to early endosome antigen 1 compartments and late endosomes, resulting in reduced surface levels
  • MARCH8 is involved direct ubiquitination of SLC3A2 and routing of SLC3A2 to late endosomes/lysosomes
  • deregulation of RHOA activation in the absence of SLC3A2 is also a result of impaired SLC3A2-dependent amino acid transports
  • HSV-1 recruited cellular fusion regulatory proteins SLC3A2 and ITGB1 to the nuclear membrane for viral de-envelopment fusion
  • cell & other
    REGULATION
    inhibited by K-RAS (negatively regulates SLC3A2 and SAT1 expression)
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --over  
    in gastric cancer
    tumoral     --over  
    has an important role to play in the metastatic process of variable neoplasms
    tumoral     --over  
    SLC3A2 and BSG were significantly upregulated in non-small cell lung cancer cells, and their expression levels were significantly correlated
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    SystemTypeDisorderPubmed
    cancer  
    association of SLC3A2 and beta(1) integrins may provide a new target for cancer therapy
    cancer  
    promising target for therapeutic modulations of cell-cell interactions
    cardiovascularatheroma 
    otential therapeutic target in vaso-occlusive disorders
    ANIMAL & CELL MODELS