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FLASH GENE

Symbol

SLC3A2

contributors: mct/npt - updated : 18-02-2018

HGNC name	solute carrier family 3 (activators of dibasic and neutral amino acid transport), member 2
HGNC id	11026

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

Location	11q12.3      Physical location : 62.623.517 - 62.656.352
Synonym name	4F2 cell-surface antigen heavy chain
	CD98 heavy chainby monoclonal antibodies 4F
	antigen defined by monoclonal antibody 4F2, heavy chain
	antigen identified 2, TRA1.10, TROP4, and T43
	CD98 heavy chain
	monoclonal antibody 44D7
	4F2 cell-surface antigen heavy chain
	lymphocyte activation antigen 4F2 large subunit
Synonym symbol(s)	MIC8, S2, CD98, 4F2HC, MDU1, 4FZHC, CD98HC, NACAE, 4T2HC, 4F2, CD98HC

DNA

TYPE	functioning gene
STRUCTURE	32.84 kb     13 Exon(s)

10 Kb 5' upstream gene genomic sequence study

MAPPING

cloned

Y

linked

N

status

confirmed

RNA

TRANSCRIPTS	type	messenger

identification nb exons type bp product Protein kDa AA specific expression Year Pubmed NM_001012661 13 - 2408 NP_001012679 - 661 - 2006 16344560 NM_001012662 12 - 2318 NP_001012680 - 631 - 2006 16344560 NM_002394 12 - 2315 NP_002385 - 630 - 2006 16344560 NM_001012663 11 - 2222 NP_001012681 - 599 - 2006 16344560 NM_001012664 10 - 2129 NP_001012682 - 568 - 2006 16344560 NM_001013251 - - 1997 NP_001013269 57 529 - 2006 16344560

EXPRESSION

Type	ubiquitous

expressed in	(based on citations)
organ(s)

cell lineage

cell lines

fluid/secretion

at STAGE

physiological period

pregnancy

Text	placenta, in developing placental trophoblast

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains	a transmembrane domain necessary and sufficient for integrin association in cells
	potential phosphorylation sites in its extracellular C-terminal tail

conjugated

GlycoP

mono polymer

heteromer , dimer

HOMOLOGY

Homologene

FAMILY	solute carrier family 3
	SLC3A transporter family

CATEGORY

antigen , transport carrier

SUBCELLULAR LOCALIZATION	extracellular
	plasma membrane
	intracellular
	intracellular,cytoplasm
	intracellular,nucleus
text	membrane protein, as an important component of the matrix assembly machinery
	is a disulfide-linked heterodimeric type II transmembrane glycoprotein

basic FUNCTION	involved in T cell activation and in normal and neoplastic cell growth
	can control the capacity of cells to assemble an Fibronectin matrix, a process important in development, wound healing, and tumorigenesis
	may cooperate with other cytoplasmic domain binding proteins to modulate integrin functions and into the evolution of integrin signaling
	involved in the export of the diamine putrescine and monoacetylated spermidine
	extracellular signaling through ecto-protein kinases (EPKs) might lead to ecto-phosphorylation of SLC3A2 and influence its multiple functions, including its role in cell-cell interactions
	mediating notoriously invasive activity of extravillous trophoblast by promoting alpha(v)beta(3) integrin-dependent signals
	importance of SLC2A3 in vascular smooth muscle cells (VSMCs) proliferation and survival
	is likely involved in integrin trafficking and by consequence, in keratinocyte adhesion and differentiation
	play an important role in the activation and functions of macrophages
	in colitis, regulates the expansion of autoimmune CD4(+) T cells in addition to controlling nTregs functions
	SLC3A2/BSG complex significantly contributes to poor prognosis of NSCLC patients through promoting cell proliferation via the PI3K/Akt pathway
	contributes to carcinogenesis by amplifying a positive feedback loop, which increases both extracellular matrix stiffness and resulting cellular responses
	CD99 and SLC3A2 oppositely regulate ITGB1 signaling

CELLULAR PROCESS

PHYSIOLOGICAL PROCESS

PATHWAY

metabolism

signaling

a component	heterodimerizing with 4F2HC chain such as SLC7A5, SLC7A7 and others
	disulfide-linked heterodimer of a glycosylated heavy chain and a nonglycosylated light chain
	component of a transporter capable of exporting the diamine putrescine
	BSG an SLC3A2 form a complex on the cell plasma membrane of several cancers
	heavy chain component of the dimeric transmembrane glycoprotein CD98, which comprises the large neutral amino acid transporter LAT1 (SLC7A5) in cells
	is a disulfide-linked 125-kDa heterodimeric type II transmembrane glycoprotein

INTERACTION

DNA

RNA

small molecule

protein	interaction with ITGB1 is required for transformation
	interacting with FAM57A and GGTL3
	SLC3A2 and SAT1 may form a complex at the plasma membrane (may interact with SLC3A2 to couple acetylation and export of the longer chain polyamines, spermidine and spermine)
	interaction with SAT1 (these proteins may be facilitate excretion of acetylated polyamines)
	MARCH8 expression completely shifted the trafficking of CD44 and SLC3A2 proteins away from recycling tubules to early endosome antigen 1 compartments and late endosomes, resulting in reduced surface levels
	MARCH8 is involved direct ubiquitination of SLC3A2 and routing of SLC3A2 to late endosomes/lysosomes
	deregulation of RHOA activation in the absence of SLC3A2 is also a result of impaired SLC3A2-dependent amino acid transports
	NCAPD3 down-regulates transcription of genes that encode amino acid transporters (SLC7A5 and SLC3A2) to promote bacterial autophagy by colon epithelial cells
	HSV-1 recruited cellular fusion regulatory proteins SLC3A2 and ITGB1 to the nuclear membrane for viral de-envelopment fusion
	SLC3A2 is transcriptionally regulated and ectopic expression of the membrane-associated RING-CH (MARCH) E3 ubiquitin ligases MARCHF1 or MARCHF8 leads to ubiquitylation and lysosomal degradation of SLC3A2

cell & other

REGULATION

inhibited by

K-RAS (negatively regulates SLC3A2 and SAT1 expression)

ASSOCIATED DISORDERS

corresponding disease(s)

Other morbid association(s)

Type Gene Modification Chromosome rearrangement Protein expression Protein Function tumoral     --over   in gastric cancer tumoral     --over   has an important role to play in the metastatic process of variable neoplasms tumoral     --over   SLC3A2 and BSG were significantly upregulated in non-small cell lung cancer cells, and their expression levels were significantly correlated

Susceptibility

Variant & Polymorphism

Candidate gene
Marker
Therapy target
	System Type Disorder Pubmed cancer     association of SLC3A2 and beta(1) integrins may provide a new target for cancer therapy cancer     promising target for therapeutic modulations of cell-cell interactions cardiovascular atheroma   otential therapeutic target in vaso-occlusive disorders

ANIMAL & CELL MODELS