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FLASH GENE
Symbol SLC3A2 contributors: mct/npt - updated : 18-02-2016
HGNC name solute carrier family 3 (activators of dibasic and neutral amino acid transport), member 2
HGNC id 11026
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
13 - 2408 - 661 - 2006 16344560
12 - 2318 - 631 - 2006 16344560
12 - 2315 - 630 - 2006 16344560
11 - 2222 - 599 - 2006 16344560
10 - 2129 - 568 - 2006 16344560
- - 1997 57 529 - 2006 16344560
EXPRESSION
Type ubiquitous
   expressed in (based on citations)
organ(s)
cell lineage
cell lines
fluid/secretion
at STAGE
physiological period pregnancy
Text placenta, in developing placental trophoblast
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • a transmembrane domain necessary and sufficient for integrin association in cells
  • potential phosphorylation sites in its extracellular C-terminal tail
  • conjugated GlycoP
    mono polymer heteromer , dimer
    HOMOLOGY
    Homologene
    FAMILY
  • solute carrier family 3
  • SLC3A transporter family
  • CATEGORY antigen , transport carrier
    SUBCELLULAR LOCALIZATION extracellular
        plasma membrane
        intracellular
    intracellular,cytoplasm
    intracellular,nucleus
    text
  • membrane protein, as an important component of the matrix assembly machinery
  • is a disulfide-linked heterodimeric type II transmembrane glycoprotein
  • basic FUNCTION
  • involved in T cell activation and in normal and neoplastic cell growth
  • can control the capacity of cells to assemble an Fibronectin matrix, a process important in development, wound healing, and tumorigenesis
  • may cooperate with other cytoplasmic domain binding proteins to modulate integrin functions and into the evolution of integrin signaling
  • involved in the export of the diamine putrescine and monoacetylated spermidine
  • extracellular signaling through ecto-protein kinases (EPKs) might lead to ecto-phosphorylation of SLC3A2 and influence its multiple functions, including its role in cell-cell interactions
  • mediating notoriously invasive activity of extravillous trophoblast by promoting alpha(v)beta(3) integrin-dependent signals
  • importance of SLC2A3 in vascular smooth muscle cells (VSMCs) proliferation and survival
  • is likely involved in integrin trafficking and by consequence, in keratinocyte adhesion and differentiation
  • play an important role in the activation and functions of macrophages
  • in colitis, regulates the expansion of autoimmune CD4(+) T cells in addition to controlling nTregs functions
  • SLC3A2/BSG complex significantly contributes to poor prognosis of NSCLC patients through promoting cell proliferation via the PI3K/Akt pathway
  • contributes to carcinogenesis by amplifying a positive feedback loop, which increases both extracellular matrix stiffness and resulting cellular responses
  • CD99 and SLC3A2 oppositely regulate ITGB1 signaling
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
  • heterodimerizing with 4F2HC chain such as SLC7A5, SLC7A7 and others
  • disulfide-linked heterodimer of a glycosylated heavy chain and a nonglycosylated light chain
  • component of a transporter capable of exporting the diamine putrescine
  • BSG an SLC3A2 form a complex on the cell plasma membrane of several cancers
  • heavy chain component of the dimeric transmembrane glycoprotein CD98, which comprises the large neutral amino acid transporter LAT1 (SLC7A5) in cells
  • is a disulfide-linked 125-kDa heterodimeric type II transmembrane glycoprotein
  • INTERACTION
    DNA
    RNA
    small molecule
    protein
  • interaction with ITGB1 is required for transformation
  • interacting with FAM57A and GGTL3
  • SLC3A2 and SAT1 may form a complex at the plasma membrane (may interact with SLC3A2 to couple acetylation and export of the longer chain polyamines, spermidine and spermine)
  • interaction with SAT1 (these proteins may be facilitate excretion of acetylated polyamines)
  • MARCH8 expression completely shifted the trafficking of CD44 and SLC3A2 proteins away from recycling tubules to early endosome antigen 1 compartments and late endosomes, resulting in reduced surface levels
  • MARCH8 is involved direct ubiquitination of SLC3A2 and routing of SLC3A2 to late endosomes/lysosomes
  • deregulation of RHOA activation in the absence of SLC3A2 is also a result of impaired SLC3A2-dependent amino acid transports
  • NCAPD3 down-regulates transcription of genes that encode amino acid transporters (SLC7A5 and SLC3A2) to promote bacterial autophagy by colon epithelial cells
  • HSV-1 recruited cellular fusion regulatory proteins SLC3A2 and ITGB1 to the nuclear membrane for viral de-envelopment fusion
  • cell & other
    REGULATION
    inhibited by K-RAS (negatively regulates SLC3A2 and SAT1 expression)
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --over  
    in gastric cancer
    tumoral     --over  
    has an important role to play in the metastatic process of variable neoplasms
    tumoral     --over  
    SLC3A2 and BSG were significantly upregulated in non-small cell lung cancer cells, and their expression levels were significantly correlated
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    SystemTypeDisorderPubmed
    cancer  
    association of SLC3A2 and beta(1) integrins may provide a new target for cancer therapy
    cancer  
    promising target for therapeutic modulations of cell-cell interactions
    cardiovascularatheroma 
    otential therapeutic target in vaso-occlusive disorders
    ANIMAL & CELL MODELS