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FLASH GENE

Symbol

SLC38A4

contributors: np/ - updated : 05-07-2007

HGNC name	solute carrier family 38, member 4
HGNC id	14679

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

Location	12q13.11      Physical location : 47.158.543 - 47.219.780
Synonym name	N amino acid transporter 3
	sodium-coupled neutral amino acid transporter 4
	Na(+)-coupled neutral amino acid transporter 4
	system N amino acid transporter
Synonym symbol(s)	ATA3, NAT3, SNAT4, PAAT, MGC126876, FLJ10191

DNA

TYPE	functioning gene
STRUCTURE	61.24 kb     17 Exon(s)

10 Kb 5' upstream gene genomic sequence study

MAPPING

cloned

Y

linked

N

status

provisional

RNA

TRANSCRIPTS	type	messenger

identification nb exons type bp product Protein kDa AA specific expression Year Pubmed NM_001143824 16 - 3807 NP_001137296 - 547 - - NM_018018 17 - 3999 NP_060488 - 547 - -

EXPRESSION

Type

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Digestive liver       highly Endocrine pancreas       lowly Urinary kidney       highly

tissue

System Tissue Tissue level 1 Tissue level 2 Level Pubmed Species Stage Rna symbol Epithelial secretory glandular endocrine   Epithelial secretory glandular exocrine   Muscular striatum skeletal

cell lineage

cell lines

fluid/secretion

at STAGE

physiological period

embryo

Text	expressed in human placental trophoblast

PROTEIN

PHYSICAL PROPERTIES		Hydrophobic
STRUCTURE

motifs/domains

ten transmembrane domains which putatively place both the amino and C terminus in the cythoplasm

HOMOLOGY

interspecies	ortholog to murine mNAT
	ortholog to rattus ata3

Homologene

FAMILY

amino acid transporters

CATEGORY

transport carrier

SUBCELLULAR LOCALIZATION

plasma membrane

basic FUNCTION	amino acid uptake likely playing an important role in arginine uptake by liver
	contribution to placental system A activity is relatively high during first trimester and decreases towards term

CELLULAR PROCESS

PHYSIOLOGICAL PROCESS

text	neutral amino acidNa(+)np; H dependent; catronic amino acids (Na+) independent

PATHWAY

metabolism

aminoacid

signaling

a component

INTERACTION

DNA

RNA

small molecule

protein

cell & other

REGULATION

ASSOCIATED DISORDERS

ANIMAL & CELL MODELS