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FLASH GENE
Symbol SLC38A4 contributors: np/ - updated : 05-07-2007
HGNC name solute carrier family 38, member 4
HGNC id 14679
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
16 - 3807 - 547 - -
17 - 3999 - 547 - -
EXPRESSION
Type
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Digestiveliver   highly
Endocrinepancreas   lowly
Urinarykidney   highly
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Epithelialsecretoryglandularendocrine 
Epithelialsecretoryglandularexocrine 
Muscularstriatumskeletal  
cell lineage
cell lines
fluid/secretion
at STAGE
physiological period embryo
Text expressed in human placental trophoblast
PROTEIN
PHYSICAL PROPERTIES Hydrophobic
STRUCTURE
motifs/domains
  • ten transmembrane domains which putatively place both the amino and C terminus in the cythoplasm
  • HOMOLOGY
    interspecies ortholog to murine mNAT
    ortholog to rattus ata3
    Homologene
    FAMILY
  • amino acid transporters
  • CATEGORY transport carrier
    SUBCELLULAR LOCALIZATION     plasma membrane
    basic FUNCTION
  • amino acid uptake likely playing an important role in arginine uptake by liver
  • contribution to placental system A activity is relatively high during first trimester and decreases towards term
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    text neutral amino acidNa(+)np; H dependent; catronic amino acids (Na+) independent
    PATHWAY
    metabolism aminoacid
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS