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FLASH GENE
Symbol SLC2A8 contributors: mct - updated : 18-03-2020
HGNC name solute carrier family 2, (facilitated glucose transporter) member 8
HGNC id 13812
Location 9q33.3      Physical location : 130.159.464 - 130.170.161
Synonym name
  • glucose transporter X1
  • glucose transporter type 8
  • Synonym symbol(s) GLUTX1, GLUT8
    DNA
    TYPE functioning gene
    STRUCTURE 10.76 kb     10 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    9 - 2030 - 411 - 2009 19229868
    8 - 1806 - 314 - 2009 19229868
    10 - 2145 50.8 477 - 2009 19229868
    EXPRESSION
    Rna function GLUT8-mRNA in hippocampus, thalamus, and cortex
    Type widely
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Cardiovascularheart   highly Homo sapiens
    Digestiveintestinelarge intestine  moderately
     liver   highly Homo sapiens
    Endocrineadrenal gland   moderately
    Nervousbrainhindbraincerebellum highlyHomo sapiens
     plexus choroid     Homo sapiens
    Reproductivemale systemtestis  predominantly
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Connectiveadiposewhite highly
    Muscularstriatumskeletal highly
    cells
    SystemCellPubmedSpeciesStageRna symbol
    Digestiveenterocyte
    Nervousependymal cell Homo sapiens
    Nervousepithelial cell Homo sapiens
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • a short extracellular loop between transmembrane domain (TM) 1and TM2 and a long loop between TM9 and TM10
  • a [D/E]XXXL[L/I]-type dileucine sorting signal that has been postulated to retain the protein in an endosomal/lysosomal compartment via interactions with clathrin adaptor protein (AP) complexes , and SLC2A8 and SLC2A12 both contain a similar [DE]XXXL[LI] dileucine sorting signal in their N- terminus
  • HOMOLOGY
    interspecies homolog to rattus Glut1-5
    Homologene
    FAMILY
  • solute carrier family 2
  • CATEGORY transport carrier
    SUBCELLULAR LOCALIZATION     plasma membrane
        intracellular
    intracellular,cytoplasm,organelle,endosome
    intracellular,cytoplasm,organelle,lysosome
    text
  • located at the plasma membrane as well as within spermatozoa in the acrosomal region
  • associated with a specific intracellular compartment in which it may play an as-yet-uncharacterized role
  • localized in a late endosomal/lysosomal compartment of spermatocytes and spermatids
  • basic FUNCTION
  • insulin regulated facilitative glucose transporter
  • transport facilitator playing a major role in the fuel supply of mature spermatozoa, and is a potential target for inhibition of sperm cell function
  • class 3 sugar transport facilitator, not playing a significant role for maintenance of whole body glucose homeostasis
  • plays an important role in the energy metabolism of sperm cells
  • potential role in the so far unexplored substrate transport across intracellular membranes
  • activities of the enigmatic transporters SLC2A8 and SLC2A11 are required for proliferation and viability in myeloma, albeit because of functionalities probably distinct from whole-cell glucose supply
  • is a facilitative glucose and fructose transporter
  • is essential for hepatocyte fructose transport and fructose-induced macrosteatosis
  • SLC2A4 and SLC2A8 trafficking is impaired in the diabetic atria and rescued by insulin treatment
  • is likely a mammalian trehalose transporter required for hepatocyte trehalose-induced autophagy and signal transduction
  • SLC2A1 and SLC2A8 both transporters are involved in glucose uptake into cis-Golgi, supporting lactose synthesis
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS facilitated diffusion transport
    PATHWAY
    metabolism carbohydrate
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • regulates enterocyte fructose transport by regulating SLC2A12, and disrupted SLC2A8 function has deleterious long-term metabolic sequelae
  • cell & other
    REGULATION
    induced by hormones
    Other recruitment of SLC2A8 to the endocytic machinery occurs via direct interaction of the dileucine motif with beta2-adaptin, and endocytosis might be the main site at which it is likely to be regulated
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    constitutional     --over  
    in human IUGR-affected pregnancies on the maternal aspect of the placenta (extravillous trophoblastic (EVT) cytoplasm) compared to control
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    SystemTypeDisorderPubmed
    cancer  
    therapeutic strategy entailing selective SLC2A4, SLC2A11, SLC2A8 inhibition to specifically target aberrant glucose metabolism in cancer
    diabetetype 2 
    is a promising target in the prevention of diet-induced obesity, and type 2 diabetes mellitus in males
    diabetemetabolic syndrom 
    is a promising target in the prevention of diet-induced obesity, metabolic syndrome in males
    ANIMAL & CELL MODELS
  • behavioral alterations of Slc2a8 -/- mice are due to dysfunctions in neuronal processes presumably as a consequence of defects in the glucose metabolism
  • Glut8KO mice exhibited significantly greater jejunal fructose uptake at baseline and after high-fructose diet (HFrD) feeding vs. wild-type mice