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FLASH GENE
Symbol SLC2A8 contributors: mct - updated : 18-03-2020
HGNC name solute carrier family 2, (facilitated glucose transporter) member 8
HGNC id 13812
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • a short extracellular loop between transmembrane domain (TM) 1and TM2 and a long loop between TM9 and TM10
  • a [D/E]XXXL[L/I]-type dileucine sorting signal that has been postulated to retain the protein in an endosomal/lysosomal compartment via interactions with clathrin adaptor protein (AP) complexes , and SLC2A8 and SLC2A12 both contain a similar [DE]XXXL[LI] dileucine sorting signal in their N- terminus
  • HOMOLOGY
    interspecies homolog to rattus Glut1-5
    Homologene
    FAMILY
  • solute carrier family 2
  • CATEGORY transport carrier
    SUBCELLULAR LOCALIZATION     plasma membrane
        intracellular
    intracellular,cytoplasm,organelle,endosome
    intracellular,cytoplasm,organelle,lysosome
    text
  • located at the plasma membrane as well as within spermatozoa in the acrosomal region
  • associated with a specific intracellular compartment in which it may play an as-yet-uncharacterized role
  • localized in a late endosomal/lysosomal compartment of spermatocytes and spermatids
  • basic FUNCTION
  • insulin regulated facilitative glucose transporter
  • transport facilitator playing a major role in the fuel supply of mature spermatozoa, and is a potential target for inhibition of sperm cell function
  • class 3 sugar transport facilitator, not playing a significant role for maintenance of whole body glucose homeostasis
  • plays an important role in the energy metabolism of sperm cells
  • potential role in the so far unexplored substrate transport across intracellular membranes
  • activities of the enigmatic transporters SLC2A8 and SLC2A11 are required for proliferation and viability in myeloma, albeit because of functionalities probably distinct from whole-cell glucose supply
  • is a facilitative glucose and fructose transporter
  • is essential for hepatocyte fructose transport and fructose-induced macrosteatosis
  • SLC2A4 and SLC2A8 trafficking is impaired in the diabetic atria and rescued by insulin treatment
  • is likely a mammalian trehalose transporter required for hepatocyte trehalose-induced autophagy and signal transduction
  • SLC2A1 and SLC2A8 both transporters are involved in glucose uptake into cis-Golgi, supporting lactose synthesis
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS facilitated diffusion transport
    PATHWAY
    metabolism carbohydrate
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • regulates enterocyte fructose transport by regulating SLC2A12, and disrupted SLC2A8 function has deleterious long-term metabolic sequelae
  • cell & other
    REGULATION
    induced by hormones
    Other recruitment of SLC2A8 to the endocytic machinery occurs via direct interaction of the dileucine motif with beta2-adaptin, and endocytosis might be the main site at which it is likely to be regulated
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    constitutional     --over  
    in human IUGR-affected pregnancies on the maternal aspect of the placenta (extravillous trophoblastic (EVT) cytoplasm) compared to control
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    SystemTypeDisorderPubmed
    cancer  
    therapeutic strategy entailing selective SLC2A4, SLC2A11, SLC2A8 inhibition to specifically target aberrant glucose metabolism in cancer
    diabetetype 2 
    is a promising target in the prevention of diet-induced obesity, and type 2 diabetes mellitus in males
    diabetemetabolic syndrom 
    is a promising target in the prevention of diet-induced obesity, metabolic syndrome in males
    ANIMAL & CELL MODELS
  • behavioral alterations of Slc2a8 -/- mice are due to dysfunctions in neuronal processes presumably as a consequence of defects in the glucose metabolism
  • Glut8KO mice exhibited significantly greater jejunal fructose uptake at baseline and after high-fructose diet (HFrD) feeding vs. wild-type mice