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FLASH GENE
Symbol SLC2A8 contributors: mct - updated : 18-03-2020
HGNC name solute carrier family 2, (facilitated glucose transporter) member 8
HGNC id 13812
ASSOCIATED DISORDERS
corresponding disease(s)
Other morbid association(s)
TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
constitutional     --over  
in human IUGR-affected pregnancies on the maternal aspect of the placenta (extravillous trophoblastic (EVT) cytoplasm) compared to control
Susceptibility
Variant & Polymorphism
Candidate gene
Marker
Therapy target
SystemTypeDisorderPubmed
cancer  
therapeutic strategy entailing selective SLC2A4, SLC2A11, SLC2A8 inhibition to specifically target aberrant glucose metabolism in cancer
diabetetype 2 
is a promising target in the prevention of diet-induced obesity, and type 2 diabetes mellitus in males
diabetemetabolic syndrom 
is a promising target in the prevention of diet-induced obesity, metabolic syndrome in males
ANIMAL & CELL MODELS
  • behavioral alterations of Slc2a8 -/- mice are due to dysfunctions in neuronal processes presumably as a consequence of defects in the glucose metabolism
  • Glut8KO mice exhibited significantly greater jejunal fructose uptake at baseline and after high-fructose diet (HFrD) feeding vs. wild-type mice