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FLASH GENE
Symbol SLC25A38 contributors: mct/npt - updated : 26-09-2009
HGNC name solute carrier family 25, member 38
HGNC id 26054
Corresponding disease
ASPR sideroblastic anemia, pyridoxine-refractory
Location 3p22.1      Physical location : 39.424.814 - 39.438.819
Synonym symbol(s) FLJ20551, FLJ22703
DNA
TYPE functioning gene
STRUCTURE 14.00 kb     7 Exon(s)
MAPPING cloned Y linked N status provisional
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
7 - 2124 - 304 - Haitina (2006)
EXPRESSION
Type ubiquitous
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Cardiovascularheart   highly
Digestiveintestinesmall intestine  highly
Lymphoid/Immunethymus   highly
Nervousbrain   highly
Reproductivefemale systemuteruscervix highly
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Blood / hematopoieticbone marrow  highly
cells
SystemCellPubmedSpeciesStageRna symbol
Blood/Hematopoieticerythroblast
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • N-terminal mitochondrial targeting signal
  • six transmembrane helices
  • four EF-hand domains
  • three solcar repeats
  • HOMOLOGY
    Homologene
    FAMILY
  • mitochondrial carrier family
  • CATEGORY transport carrier
    SUBCELLULAR LOCALIZATION     plasma membrane
        intracellular
    intracellular,cytoplasm,organelle,mitochondria,inner
    intracellular,cytoplasm,organelle,membrane
    basic FUNCTION
  • calcium-dependent mitochondrial solute carrier
  • erythroid specific mitochondrial carrier, important for the biosynthesis of heme in eukaryotes (Guernsey 2009)
  • may be facilitates ALA production by importing glycine into mitochondria or by exchanging glycine for ALA across the mitochondrial inner membrane (Guernsey 2009)
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s) ASPR
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS