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FLASH GENE
Symbol SLC25A38 contributors: mct/npt - updated : 02-11-2020
HGNC name solute carrier family 25, member 38
HGNC id 26054
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • N-terminal mitochondrial targeting signal
  • six transmembrane helices
  • four EF-hand domains
  • three solcar repeats
  • HOMOLOGY
    interspecies homolog to yeast Hem25
    Homologene
    FAMILY
  • mitochondrial carrier family
  • CATEGORY transport carrier
    SUBCELLULAR LOCALIZATION     plasma membrane
        intracellular
    intracellular,cytoplasm,organelle,mitochondria,inner
    intracellular,cytoplasm,organelle,membrane
    basic FUNCTION
  • calcium-dependent mitochondrial solute carrier
  • erythroid specific mitochondrial carrier, important for the biosynthesis of heme in eukaryotes (Guernsey 2009)
  • may be facilitates ALA production by importing glycine into mitochondria or by exchanging glycine for ALA across the mitochondrial inner membrane (Guernsey 2009)
  • is a pro-apoptotic protein, which regulates intrinsic caspase-dependent apoptosis
  • main mitochondrial glycine transporters required for heme synthesis
  • mitochondrial glycine transporter that provides substrate to initiate heme/hemoglobin synthesis
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • can interact with mitochondrial outer-membrane fusion proteins and regulates mitochondrial morphology
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s) ASPR
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    SystemTypeDisorderPubmed
    cancerhemopathy 
    potential therapeutic target for ALL
    ANIMAL & CELL MODELS