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FLASH GENE
Symbol SLC25A38 contributors: mct/npt - updated : 02-11-2020
HGNC name solute carrier family 25, member 38
HGNC id 26054
EXPRESSION
Type ubiquitous
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Cardiovascularheart   highly
Digestiveintestinesmall intestine  highly
Lymphoid/Immunethymus   highly
Nervousbrain   highly
Reproductivefemale systemuteruscervix highly
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Blood / hematopoieticbone marrow  highly
cells
SystemCellPubmedSpeciesStageRna symbol
Blood/Hematopoieticerythroblast
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • N-terminal mitochondrial targeting signal
  • six transmembrane helices
  • four EF-hand domains
  • three solcar repeats
  • HOMOLOGY
    interspecies homolog to yeast Hem25
    Homologene
    FAMILY
  • mitochondrial carrier family
  • CATEGORY transport carrier
    SUBCELLULAR LOCALIZATION     plasma membrane
        intracellular
    intracellular,cytoplasm,organelle,mitochondria,inner
    intracellular,cytoplasm,organelle,membrane
    basic FUNCTION
  • calcium-dependent mitochondrial solute carrier
  • erythroid specific mitochondrial carrier, important for the biosynthesis of heme in eukaryotes (Guernsey 2009)
  • may be facilitates ALA production by importing glycine into mitochondria or by exchanging glycine for ALA across the mitochondrial inner membrane (Guernsey 2009)
  • is a pro-apoptotic protein, which regulates intrinsic caspase-dependent apoptosis
  • main mitochondrial glycine transporters required for heme synthesis
  • mitochondrial glycine transporter that provides substrate to initiate heme/hemoglobin synthesis
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • can interact with mitochondrial outer-membrane fusion proteins and regulates mitochondrial morphology
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s) ASPR
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    SystemTypeDisorderPubmed
    cancerhemopathy 
    potential therapeutic target for ALL
    ANIMAL & CELL MODELS