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FLASH GENE
Symbol SLC25A15 contributors: mct/npt - updated : 13-11-2009
HGNC name solute carrier family 25 (mitochondrial carrier; ornithine transporter) member 15
HGNC id 10985
Corresponding disease
HHH hyperornithinemia-hyperammonemia-homocitrullinuria syndrome
Location 13q14.11      Physical location : 41.363.546 - 41.386.595
Synonym name
  • ornithine transporter 1
  • mitochondrial ornithine transporter 1
  • Synonym symbol(s) ORNT1, D13S327, ORC1
    DNA
    TYPE functioning gene
    STRUCTURE 20.65 kb     7 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    regulatory sequence
    MAPPING cloned Y linked   status provisional
    Physical map
    STOML3 13q13.2 stomatin (EPB72)-like 3 FLJ12661 13q13.3 hypothetical protein FLJ12661 LOC387921 13 similar to RIKEN cDNA 8030451K01 LOC390397 13 similar to NTF2-related export protein 1 (p15 protein) LHFP 13q12 lipoma HMGIC fusion partner COG6 13q13.3 component of oligomeric golgi complex 6 FOXO1A 13q14.1 forkhead box O1A (rhabdomyosarcoma) MRPS31 13q13.2 mitochondrial ribosomal protein S31 SLC25A15 13q14 solute carrier family 25 (mitochondrial carrier; ornithine transporter) member 15 HCP34 13q14.11 cytochrome c, somatic pseudogene ELF1 13q13 E74-like factor 1 (ets domain transcription factor) WBP4 13q13.3 WW domain binding protein 4 (formin binding protein 21) KBTBD6 13q13.3 kelch repeat and BTB (POZ) domain containing 6 LOC390398 13 similar to calmodulin 1; Calmodulin 1 (phosphorylase kinase, delta) KBTBD7 13q13.3 kelch repeat and BTB (POZ) domain containing 7 MTRF1 13q14.1-q14.3 mitochondrial translational release factor 1 FLJ22054 13q13.3 hypothetical protein FLJ22054 LOC387922 13 similar to tubulin, beta 5 LOC390399 13 similar to olfactory receptor MOR145-1 OR7E37P 13q14.12 olfactory receptor, family 7, subfamily E, member 37 pseudogene RGC32 13q13.3 response gene to complement 32 KIAA0564 13q13.3 KIAA0564 protein DGKH 13q13.3 diacylglycerol kinase, eta MAPK6PS3 13q14.13 diacylglycerol kinase, eta LOC341651 13q13.3 similar to bA215B13.2 (fumarate hydratase (FH) pseudogene) AKAP11 13q14.3 a kinase (PRKA) anchor protein 11 FABP3P2 13q13-q14 fatty acid binding protein 3, pseudogene 2
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    7 - 4038 - 301 - Tessa (2009)
    EXPRESSION
    Type widely
    constitutive of
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Cardiovascularheart   highly
    Digestiveliver   highly
    Endocrinethyroid    
    Reproductivefemale systemuteruscervix highly
    Visualeyeuveachoroid  
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Connectiveadipose  highly
    Epithelialbarrier/liningretinal pigment epithelium (RPE)  
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • three SOLCAR repeats
  • HOMOLOGY
    interspecies homolog to murine Slc25a15
    intraspecies homolog to SLC25A2
    Homologene
    FAMILY
  • mitochondrial carrier family
  • CATEGORY transport carrier
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,organelle,mitochondria,inner
    intracellular,cytoplasm,organelle,membrane
    basic FUNCTION
  • involved in the ornithine transport across inner mitochondrial membrane, from the cytoplasm to the matrix
  • mitochondrial carrier protein, which catalyzes the
  • electroneutral exchange of ornithine for citrulline plus an H1 ion (Tessa 2009)
    CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS mitochondrial transport
    PATHWAY
    metabolism aminoacid
    signaling
    urea cycle
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s) HHH
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS