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FLASH GENE
Symbol SLC25A15 contributors: mct/npt - updated : 13-11-2009
HGNC name solute carrier family 25 (mitochondrial carrier; ornithine transporter) member 15
HGNC id 10985
EXPRESSION
Type widely
constitutive of
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Cardiovascularheart   highly
Digestiveliver   highly
Endocrinethyroid    
Reproductivefemale systemuteruscervix highly
Visualeyeuveachoroid  
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Connectiveadipose  highly
Epithelialbarrier/liningretinal pigment epithelium (RPE)  
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • three SOLCAR repeats
  • HOMOLOGY
    interspecies homolog to murine Slc25a15
    intraspecies homolog to SLC25A2
    Homologene
    FAMILY
  • mitochondrial carrier family
  • CATEGORY transport carrier
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,organelle,mitochondria,inner
    intracellular,cytoplasm,organelle,membrane
    basic FUNCTION
  • involved in the ornithine transport across inner mitochondrial membrane, from the cytoplasm to the matrix
  • mitochondrial carrier protein, which catalyzes the
  • electroneutral exchange of ornithine for citrulline plus an H1 ion (Tessa 2009)
    CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS mitochondrial transport
    PATHWAY
    metabolism aminoacid
    signaling
    urea cycle
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s) HHH
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS