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FLASH GENE

Symbol

SLC20A2

contributors: mct - updated : 11-12-2016

HGNC name	solute carrier family 20 (phosphate transporter), member 2
HGNC id	10947

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

Corresponding disease	BGCI1 basal ganglia cancification, idiopathic, 1
Location	8p11.21      Physical location : 42.273.994 - 42.397.068
Synonym name	gibbon ape leukemia virus receptor 2, Moloney murine leukemia virus receptor
	murine leukemia virus, amphotropic, receptor
	type III sodium-dependent phosphate transporter 2
Synonym symbol(s)	D8S1915, GLVR2, MLVAR, PIT2, GLVR-2, IBGC1, IBGC3, PIT-2, RAM1

DNA

TYPE	functioning gene
STRUCTURE	123.38 kb     11 Exon(s)

10 Kb 5' upstream gene genomic sequence study

MAPPING

cloned

Y

linked

status

provisional

RNA

TRANSCRIPTS	type	messenger

identification nb exons type bp product Protein kDa AA specific expression Year Pubmed NM_006749 11 - 3971 NP_006740 - 652 - 2010 20817733 NP_006740 11 - 3639 NP_001244110 - 652 - 2010 20817733 NM_001257180 11 - 4008 NP_001244109 - 652 - 2010 20817733

EXPRESSION

Type	ubiquitous

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Digestive mouth       highly Nervous brain       highly Respiratory respiratory tract larynx     highly   respiratory tract trachea     highly Urinary kidney tubule convoluted tubule proximal tubule   Rattus norvegicus

cells

System Cell Pubmed Species Stage Rna symbol Urinary epithelial cell Rattus norvegicus

cell lineage

cell lines

fluid/secretion

at STAGE

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains

HOMOLOGY

interspecies

homolog to murine Slc20a2

Homologene

FAMILY

phosphatase transporter family, PiT family

CATEGORY

unknown/unspecified , receptor , transport channel

SUBCELLULAR LOCALIZATION

plasma membrane

basic FUNCTION	transporter capable of Na(+)-independent P(i) transport at acidic pH
	modify its oligomerization independently of Pi (inorganic phosphate) uptake in response to changes in the extracellular Pi concentration, suggesting a possible role in Pi sensing
	SLC20A2 and XPR1 are transporters with phosphate uptake and efflux functions, respectively
	SLC20A2-XPR1 interplay that depends on inositol polyphosphate (IP) such as PP-IPs and controls cellular phosphate homeostasis via the efflux route, and alteration of this interplay likely contributes to primary familial brain calcification (PFBC)

CELLULAR PROCESS

PHYSIOLOGICAL PROCESS

PATHWAY

metabolism

signaling

a component

INTERACTION

DNA

RNA

small molecule

protein	receptor for amphotropic murine leukemia virus (A-MuLV) and 10A1 MuLV
	NELL1 increases pre-osteoblast mineralization using both phosphate transporter SLC20A1, SLC20A2

cell & other

REGULATION

ASSOCIATED DISORDERS

corresponding disease(s)

BGCI1

Susceptibility

Variant & Polymorphism

Candidate gene

Marker

Therapy target

ANIMAL & CELL MODELS