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FLASH GENE
Symbol SLC20A2 contributors: mct - updated : 11-12-2016
HGNC name solute carrier family 20 (phosphate transporter), member 2
HGNC id 10947
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
11 - 3971 - 652 - 2010 20817733
11 - 3639 - 652 - 2010 20817733
11 - 4008 - 652 - 2010 20817733
EXPRESSION
Type ubiquitous
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Digestivemouth   highly
Nervousbrain   highly
Respiratoryrespiratory tractlarynx  highly
 respiratory tracttrachea  highly
Urinarykidneytubuleconvoluted tubuleproximal tubule  Rattus norvegicus
cells
SystemCellPubmedSpeciesStageRna symbol
Urinaryepithelial cell Rattus norvegicus
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
HOMOLOGY
interspecies homolog to murine Slc20a2
Homologene
FAMILY phosphatase transporter family, PiT family
CATEGORY unknown/unspecified , receptor , transport channel
SUBCELLULAR LOCALIZATION     plasma membrane
basic FUNCTION
  • transporter capable of Na(+)-independent P(i) transport at acidic pH
  • modify its oligomerization independently of Pi (inorganic phosphate) uptake in response to changes in the extracellular Pi concentration, suggesting a possible role in Pi sensing
  • SLC20A2 and XPR1 are transporters with phosphate uptake and efflux functions, respectively
  • SLC20A2-XPR1 interplay that depends on inositol polyphosphate (IP) such as PP-IPs and controls cellular phosphate homeostasis via the efflux route, and alteration of this interplay likely contributes to primary familial brain calcification (PFBC)
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • receptor for amphotropic murine leukemia virus (A-MuLV) and 10A1 MuLV
  • NELL1 increases pre-osteoblast mineralization using both phosphate transporter SLC20A1, SLC20A2
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s) BGCI1
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS