basic FUNCTION
| transporter capable of Na(+)-independent P(i) transport at acidic pH |
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modify its oligomerization independently of Pi (inorganic phosphate) uptake in response to changes in the extracellular Pi concentration, suggesting a possible role in Pi sensing |
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SLC20A2 and XPR1 are transporters with phosphate uptake and efflux functions, respectively |
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SLC20A2-XPR1 interplay that depends on inositol polyphosphate (IP) such as PP-IPs and controls cellular phosphate homeostasis via the efflux route, and alteration of this interplay likely contributes to primary familial brain calcification (PFBC) |
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