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FLASH GENE
Symbol SLC20A2 contributors: mct - updated : 11-12-2016
HGNC name solute carrier family 20 (phosphate transporter), member 2
HGNC id 10947
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
HOMOLOGY
interspecies homolog to murine Slc20a2
Homologene
FAMILY phosphatase transporter family, PiT family
CATEGORY unknown/unspecified , receptor , transport channel
SUBCELLULAR LOCALIZATION     plasma membrane
basic FUNCTION
  • transporter capable of Na(+)-independent P(i) transport at acidic pH
  • modify its oligomerization independently of Pi (inorganic phosphate) uptake in response to changes in the extracellular Pi concentration, suggesting a possible role in Pi sensing
  • SLC20A2 and XPR1 are transporters with phosphate uptake and efflux functions, respectively
  • SLC20A2-XPR1 interplay that depends on inositol polyphosphate (IP) such as PP-IPs and controls cellular phosphate homeostasis via the efflux route, and alteration of this interplay likely contributes to primary familial brain calcification (PFBC)
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • receptor for amphotropic murine leukemia virus (A-MuLV) and 10A1 MuLV
  • NELL1 increases pre-osteoblast mineralization using both phosphate transporter SLC20A1, SLC20A2
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s) BGCI1
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS