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FLASH GENE
Symbol SLC1A4 contributors: KTN - updated : 13-12-2007
HGNC name solute carrier family 1 (glutamate/neutral amino acid transporter), member 4
HGNC id 10942
Location 2p13.3      Physical location : 65.215.578 - 65.250.997
Synonym name
  • Alanine/serine/cysteine/ threonine transporter 1
  • Synonym symbol(s) ASCT1, SATT
    DNA
    TYPE functioning gene
    STRUCTURE 34.00 kb     8 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status provisional
    Physical map
    KIAA0903 2p15 similar to DNA cytosine methyltransferase 3 alpha isoform a; DNA methyltransferase HsaIIIA; DNA MTase HsaIIIA; DNA cytosine methyltransferase 3A2 OTX1 2p13 orthodenticle homolog 1 (Drosophila) LOC51057 2p15 hypothetical protein LOC51057 MDH1 2p16 malate dehydrogenase 1, NAD (soluble) LOC388955 2 similar to Px19-like protein (25 kDa protein of relevant evolutionary and lymphoid interest) (PRELI) (CGI-106) (SBBI12) LOC391377 2 similar to ribosomal protein S4 LOC391378 2 similar to Heterogeneous nuclear ribonucleoprotein A1 (Helix-destabilizing protein) (Single-strand binding protein) (hnRNP core protein A1) (HDP-1) (Topoisomerase-inhibitor suppressed) UGP2 2p14-p13 UDP-glucose pyrophosphorylase 2 VPS54 2p13-p14 vacuolar protein sorting 54 (yeast) PELI1 2p13.3 pellino homolog 1 (Drosophila) LOC130773 2p15 similar to 60S ribosomal protein L23a HSPC159 2p15 HSPC159 protein FLJ20080 2p15 hypothetical protein FLJ20080 TRIP-Br2 2p15 transcriptional regulator interacting with the PHS-bromodomain 2 SLC1A4 2p13.3 solute carrier family 1 (glutamate/neutral amino acid transporter), member 4 LOC200731 2p14 hypothetical LOC200731 KIAA0582 2p14 hypothetical LOC200731 RAB1A 2p14 RAB1A, member RAS oncogene family LOC150984 2p14 similar to voltage-dependent anion channel isoform 2 ACTR2 2p14 ARP2 actin-related protein 2 homolog (yeast) SPRED2 2p14 sprouty-related, EVH1 domain containing 2 LOC388956 2 LOC388956 LOC391379 2 similar to DnaJ homolog subfamily B member 12 LOC391380 2 similar to Keratin, type I cytoskeletal 18 (Cytokeratin 18) (K18) (CK 18) MEIS1 2p14-p13 Meis1, myeloid ecotropic viral integration site 1 homolog (mouse) LOC391381 2 similar to DNA cytosine methyltransferase 3 alpha isoform a; DNA methyltransferase HsaIIIA; DNA MTase HsaIIIA; DNA cytosine methyltransferase 3A2
    regionally located in the PARK3 region
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    8 - 4562 55 532 - -
    EXPRESSION
    Type
    constitutive of
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Digestivemouthtongue  moderately
    Endocrineadrenal gland   highly
     pancreas    
    Lymphoid/Immunethymus   moderately
    Nervousbrain   moderately
    Reproductivefemale systemuteruscervix moderately
     female systembreastmammary gland moderately
    Respiratoryrespiratory tracttrachea  moderately
    Skin/Tegumentskin   moderately
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Connectivebone  moderately
    Epithelialsecretoryglandularendocrine 
    Epithelialsecretoryglandularexocrine 
    Muscular    
    cell lineage
    cell lines
    fluid/secretion moderately in blood and predominantly in lymph
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • ten transmembrane spanning segments (10TM)
  • conjugated GlycoP , PhosphoP
    HOMOLOGY
    interspecies homolog to dog SLC1A4 (93.2 pc)
    homolog to chimpanzee SLC1A4 (100 pc)
    homolog to rattus Slc1a4 (88.1 pc)
    homolog to murine Slc1a4 (89.9 pc)
    Homologene
    FAMILY
  • solute carrier family 1, glutamate/neutral amino acid
  • sodium:dicarboxylate (SDF) symporter (TC 2.A.23) family
  • CATEGORY transport carrier
    SUBCELLULAR LOCALIZATION     plasma membrane
    text
  • melanosome
  • basic FUNCTION
  • acting as a transporter for alanine, serine, cysteine, and threonine
  • exhibiting sodium dependence
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS