Selected-GenAtlas references | SOURCE | GeneCards | NCBI Gene | Swiss-Prot | Ensembl |
HGNC | UniGene | Nucleotide | OMIM | UCSC |
Home Page |
FLASH GENE |
Symbol | SLC10A2 | contributors: mctnpt - updated : 09-10-2018 |
HGNC name | solute carrier family 10 (sodium/bile acid cotransporter family), member 2 |
HGNC id | 10906 |
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Corresponding disease |
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Location | 13q33.1 Physical location : 103.696.349 - 103.719.196 | ||
Synonym name | |||
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Synonym symbol(s) | ASBT, ISBT, NTCP2, IBAT, PBAM |
DNA |
TYPE | functioning gene |
STRUCTURE | 22.85 kb 6 Exon(s) |
10 Kb 5' upstream gene genomic sequence study |
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MAPPING | cloned | Y | linked | N | status | provisional |
RNA |
TRANSCRIPTS | type | messenger |
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EXPRESSION |
Type | restricted |
cell lineage
cell lines
| fluid/secretion
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at STAGE |
PROTEIN |
PHYSICAL PROPERTIES
STRUCTURE
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motifs/domains
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conjugated | GlycoP |
mono polymer | homomer , monomer , dimer |
HOMOLOGY |
interspecies | homolog to rattus Slc10a2 (83.0pc) |
homolog to murine Slc10a2 (80.7pc) |
intraspecies | paralog to SLC10A6 |
Homologene |
FAMILY | |
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CATEGORY | transport carrier |
SUBCELLULAR LOCALIZATION | plasma membrane |
text | integral to plasma membrane |
basic FUNCTION | |
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CELLULAR PROCESS |
PHYSIOLOGICAL PROCESS |
text | |
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PATHWAY |
metabolism | lipid/lipoprotein |
signaling |
a component | |
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INTERACTION |
DNA |
RNA |
small molecule | metal binding, |
protein | |
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cell & other |
REGULATION |
inhibited by | ileal SLC10A2 protein is degraded by a ubiquitin-dependent pathway in response to enterobacteria-associated bile acids |
Other | positively regulated by retinoic acid (Neimark 2004) |
negative feedback regulation induced by bile acids, via an FXR-mediated, SHP-dependent effect upon RAR/RXR activation of ASBT (Neimark 2004) | |
regulated by PPAR-alpha (Jung 2002) | |
undergoes ubiquitin-proteasome degradation under basal condition in choliangiogytes (Xia 2004) | |
regulation of the SLC10A2 involves bile acids (BAs) and cholesterol | |
N-glycosylation is essential for ileal SLC10A2 function and protection against proteases |
ASSOCIATED DISORDERS |
corresponding disease(s) | PBAM |
Other morbid association(s) |
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Susceptibility |
Variant & Polymorphism other | haplotype carriers with the minor allele showed significant reduced SLC10A2 mRNA and protein expressions (Renner 2009) |
Candidate gene
Marker
| Therapy target
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ANIMAL & CELL MODELS |