Selected-GenAtlas references	SOURCE	GeneCards	NCBI Gene	Swiss-Prot	Ensembl
	HGNC	UniGene	Nucleotide	OMIM	UCSC

Home Page

FLASH GENE

Symbol

SLC10A2

contributors: mctnpt - updated : 09-10-2018

HGNC name	solute carrier family 10 (sodium/bile acid cotransporter family), member 2
HGNC id	10906

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

ASSOCIATED DISORDERS

corresponding disease(s)

PBAM

Other morbid association(s)

Type Gene Modification Chromosome rearrangement Protein expression Protein Function constitutional       loss of function might lead to some diseases associated with disorders in the enterohepatic circulation of bile acids (BAs) and cholesterol homeostasis, such as diarrhoea and gallstones constitutional     --other   is aberrantly expressed in esophageal metaplasia that also expresses CDX transcription factors (pMID: 22016432) constitutional     --over   play a crucial role in Necrotizing enterocolitis (NEC) pathogenesis, suggesting that inhibition of SLC10A2 could be utilized as a therapeutic modality against this disease

Susceptibility

Variant & Polymorphism other	haplotype carriers with the minor allele showed significant reduced SLC10A2 mRNA and protein expressions (Renner 2009)

Candidate gene
Marker
Therapy target
	System Type Disorder Pubmed digestive     inhibition of SLC10A2 could be utilized as a therapeutic modality against Necrotizing enterocolitis (NEC)

ANIMAL & CELL MODELS

Asbt-deficient mice had a striking, 2-fold increase in the number of colon adenocarcinomas