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FLASH GENE
Symbol SH3BP5 contributors: - updated : 13-01-2007
HGNC name SH3-domain binding protein 5 (BTK-associated)
HGNC id 10827
Location 3p24.3      Physical location : 15.296.356 - 15.382.901
Synonym name SH3 binding protein
Synonym symbol(s) SAB
DNA
TYPE functioning gene
STRUCTURE 86.00 kb     9 Exon(s)
10 Kb 5' upstream gene genomic sequence study
MAPPING cloned Y linked   status confirmed
Physical map
HDAC11 3p25.1 histone deacetylase 11 FBLN2 3p25-p24 fibulin 2 WNT7A 3p25 wingless-type MMTV integration site family, member 7A FLJ35107 3p25.1 hypothetical protein FLJ35107 LOC391515 3 similar to putative pheromone receptor gV1R1 FLJ31709 MGC3222 3p25.1 hypothetical protein MGC3222 XPC 3p25.1 xeroderma pigmentosum, complementation group C LSM3 3p25.1 LSM3 homolog, U6 small nuclear RNA associated (S. cerevisiae) SLC6A6 3p25-p24 solute carrier family 6 (neurotransmitter transporter, taurine), member 6 GRIP2 3p24-p23 glutamate receptor interacting protein 2 LOC131973 3p25.1 similar to rhomboid family 1; epidermal growth factor receptor, related sequence LOC51244 3p25.1 hypothetical protein LOC51244 DKFZP434N1817 3p25.1 hypothetical protein DKFZp434N1817 FGD5 3p25.1 FYVE, RhoGEF and PH domain containing 5 NR2C2 3p25 nuclear receptor subfamily 2, group C, member 2 MRPS25 3p25 mitochondrial ribosomal protein S25 ZFYVE20 3p25.1 zinc finger, FYVE domain containing 20 LOC344875 3p25.1 similar to RIKEN cDNA E330026B02 CAPN7 3p24 calpain 7 SH3BP5 1q43 SH3-domain binding protein 5 (BTK-associated) LOC389097 3 similar to Nonhistone chromosomal protein HMG-17 (High-mobility group nucleosome binding domain 2) MGC24132 3p25.1 hypothetical protein MGC24132 EAF1 3q25.1 ELL associated factor 1 COLQ 3p24.2 collagen-like tail subunit (single strand of homotrimer) of asymmetric acetylcholinesterase HPCL2 3p25.1 2-hydroxyphytanoyl-CoA lyase BTD 3p25 biotinidase KIAA0379 3p25.2-p24.2 biotinidase LOC131961 3p25.1 similar to inosine monophosphate dehydrogenase 1 isoform a; sWSS2608 GALNT7 4q31.1 UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase 7 (GalNAc-T7) MGC15763 3p25-p24 hypothetical protein BC008322 RAFTLIN 3p25.1 raft-linking protein DAZL 3p24 deleted in azoospermia-like PLCL2 3p24.3 phospholipase C-like 2
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
- - 2810 - 455 - Wiltshire
- - 2723 - 298 - Wiltshire
EXPRESSION
Type ubiquitous
constitutive of
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Endocrineadrenal gland   highly
 neuroendocrinepituitary  highly
 parathyroid   highly
Hearing/Equilibriumearinnercochlea highly
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • N-terminal KIM (KIM1)
  • lacking a proline rich sequence
  • HOMOLOGY
    Homologene
    FAMILY
    CATEGORY adaptor
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,organelle,mitochondria
    basic FUNCTION
  • BTK-associated negative transregulator
  • playing a role in the BTK signal transduction pathway
  • playing a possible role in targeting JNK to this subcellular compartment and/or mediating crosstalk between different signal-transduction pathways
  • may be involved in BCR-induced apoptotic cell death
  • plays a negative regulatory role in BTK-related
  • cytoplasmic signaling in B-cells
    CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling signal transduction
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • JNK-interacting protein, through a mitogen-activated protein KIM (kinase interaction motif) in a region distinct from the Bruton's tyrosine kinase-binding domain
  • interact with the Src homology 3 domain of Bruton's tyrosine kinase
  • interacts with all isoforms of MAPK8, MAPK9, MAPK10 and MAPK12
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS