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FLASH GENE

Symbol

SH3BP5

contributors: mct - updated : 27-03-2019

HGNC name	SH3-domain binding protein 5 (BTK-associated)
HGNC id	10827

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

Location	3p25.1      Physical location : 15.296.356 - 15.382.901
Synonym name	SH3 binding protein
Synonym symbol(s)	SAB, SH3BP-5

DNA

TYPE	functioning gene
STRUCTURE	87.04 kb     9 Exon(s)

10 Kb 5' upstream gene genomic sequence study

MAPPING

cloned

Y

linked

status

confirmed

RNA

TRANSCRIPTS	type	messenger

identification nb exons type bp product Protein kDa AA specific expression Year Pubmed NM_004844 9 - 3322 NP_004835 - 455 - 2002 12167088 NM_001018009 9 - 3203 NP_001018009 - 298 - 2002 12167088

EXPRESSION

Type	ubiquitous

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Endocrine adrenal gland       highly   neuroendocrine pituitary     highly   parathyroid       highly Hearing/Equilibrium ear inner cochlea   highly

cell lineage

cell lines

fluid/secretion

at STAGE

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains	N-terminal KIM (KIM1)
	lacking a proline rich sequence
	V-shaped structure comprising two coiled coils , and the coiled-coil architecture mediates exchange through a unique Rab-GEF interaction

HOMOLOGY

Homologene

FAMILY

CATEGORY

adaptor

SUBCELLULAR LOCALIZATION	intracellular
	intracellular,cytoplasm,organelle,mitochondria
	intracellular,cytoplasm,cytosolic,vesicle
	intracellular,nucleus,nucleoplasm,nuclear bodies

basic FUNCTION	BTK-associated negative transregulator
	playing a role in the BTK signal transduction pathway
	playing a possible role in targeting JNK to this subcellular compartment and/or mediating crosstalk between different signal-transduction pathways
	may be involved in BCR-induced apoptotic cell death
	plays a negative regulatory role in BTK-related
	cytoplasmic signaling in B-cells
	mitochondrial SH3BP5 may serve as a platform for the MAPK pathway enzymes and that the interaction of stress-activated MAPK8 with SH3BP5 is required for sustained MAPK8 activation and toxicity

CELLULAR PROCESS

PHYSIOLOGICAL PROCESS

PATHWAY

metabolism

signaling

signal transduction

a component

INTERACTION

DNA

RNA

small molecule

protein	JNK-interacting protein, through a mitogen-activated protein KIM (kinase interaction motif) in a region distinct from the Bruton's tyrosine kinase-binding domain
	interact with the Src homology 3 domain of Bruton's tyrosine kinase
	MTRNR2L1 increased the mRNA and protein expression of SH3BP5, which has been known to be a JNK interactor, in neuronal cells
	ER stress triggers an interaction of MAPK8 with mitochondrial SH3BP5, which leads to impaired respiration and increased mitochondrial reactive oxygen species, sustaining MAPK8 activation culminating in apoptosis
	interacts with all isoforms of MAPK8, MAPK9, MAPK10 and MAPK12
	SH3BP5, exhibits strong GEF activity toward human RAB11A
	essential interactions between SH3BP5 and RAB11 family proteins for the GEF reaction on recycling endosomes
	SH3BP5 interacts with the N-terminal region, switch I, interswitch, and switch II of RAB11A
	SH3BP5 and SH3BP5-like (SH3BP5L) proteins have recently been found to serve as guanine nucleotide exchange factors (GEF) for RAB11

cell & other

REGULATION

ASSOCIATED DISORDERS

ANIMAL & CELL MODELS