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FLASH GENE
Symbol SH3BP5 contributors: mct - updated : 27-03-2019
HGNC name SH3-domain binding protein 5 (BTK-associated)
HGNC id 10827
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • N-terminal KIM (KIM1)
  • lacking a proline rich sequence
  • V-shaped structure comprising two coiled coils , and the coiled-coil architecture mediates exchange through a unique Rab-GEF interaction
  • HOMOLOGY
    Homologene
    FAMILY
    CATEGORY adaptor
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,organelle,mitochondria
    intracellular,cytoplasm,cytosolic,vesicle
    intracellular,nucleus,nucleoplasm,nuclear bodies
    basic FUNCTION
  • BTK-associated negative transregulator
  • playing a role in the BTK signal transduction pathway
  • playing a possible role in targeting JNK to this subcellular compartment and/or mediating crosstalk between different signal-transduction pathways
  • may be involved in BCR-induced apoptotic cell death
  • plays a negative regulatory role in BTK-related
  • cytoplasmic signaling in B-cells
  • mitochondrial SH3BP5 may serve as a platform for the MAPK pathway enzymes and that the interaction of stress-activated MAPK8 with SH3BP5 is required for sustained MAPK8 activation and toxicity
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling signal transduction
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • JNK-interacting protein, through a mitogen-activated protein KIM (kinase interaction motif) in a region distinct from the Bruton's tyrosine kinase-binding domain
  • interact with the Src homology 3 domain of Bruton's tyrosine kinase
  • MTRNR2L1 increased the mRNA and protein expression of SH3BP5, which has been known to be a JNK interactor, in neuronal cells
  • ER stress triggers an interaction of MAPK8 with mitochondrial SH3BP5, which leads to impaired respiration and increased mitochondrial reactive oxygen species, sustaining MAPK8 activation culminating in apoptosis
  • interacts with all isoforms of MAPK8, MAPK9, MAPK10 and MAPK12
  • SH3BP5, exhibits strong GEF activity toward human RAB11A
  • essential interactions between SH3BP5 and RAB11 family proteins for the GEF reaction on recycling endosomes
  • SH3BP5 interacts with the N-terminal region, switch I, interswitch, and switch II of RAB11A
  • SH3BP5 and SH3BP5-like (SH3BP5L) proteins have recently been found to serve as guanine nucleotide exchange factors (GEF) for RAB11
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS