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FLASH GENE
Symbol SEMA6B contributors: - updated : 23-01-2006
HGNC name sema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6B
HGNC id 10739
Location 19p13.3      Physical location : 4.542.599 - 4.558.503
Synonym name semaphorin RS, short form
Synonym symbol(s) SEMAN, MAZ, SEMAZ, SEMA-VIB, SEM-SEMA-Y
DNA
TYPE functioning gene
STRUCTURE 15.00 kb     17 Exon(s)
10 Kb 5' upstream gene genomic sequence study
MAPPING cloned Y linked N status provisional
Physical map
LOC388494 19 hypothetical gene supported by AL365406; BC034005 ATCAY 19p13.3 ataxia, cerebellar, Cayman type (caytaxin) ITGB1BP3 19p13.3 integrin beta 1 binding protein 3 DAPK3 19p13.3 death-associated protein kinase 3 EEF2 19p13.3 eukaryotic translation elongation factor 2 PIASY 19p13.3 protein inhibitor of activated STAT protein PIASy LOC387622 19 hypothetical gene supported by NM_020224 FBI1 MAP2K2 7q32 mitogen-activated protein kinase kinase 2 CREB3L3 19p13.3 cAMP responsive element binding protein 3-like 3 SIRT6 19p13.3 sirtuin (silent mating type information regulation 2 homolog) 6 (S. cerevisiae) KIAA1981 EBI3 19p13.3 Epstein-Barr virus induced gene 3 FLJ10374 19p13.3 hypothetical protein FLJ10374 SHD 19p13.3 src homology 2 domain-containing transforming protein D MGC23244 19p13.3 hypothetical protein MGC23244 FSD1 19p13.3 fibronectin type 3 and SPRY (spla, ryanodine) domain containing (with coiled-coil motif) 1 STAP2 19p13.3 signal-transducing adaptor protein-2 FLJ14981 19p13.3 hypothetical protein FLJ14981 SH3GL1 19p13.3 SH3-domain GRB2-like 1 CHAF1A 19p13.3 chromatin assembly factor 1, subunit A (p150) UBXD1 19p13 UBX domain containing 1 MGC2641 19p13.3 hepatoma-derived growth factor-related protein 2 FLJ20700 19p13.3 hypothetical protein FLJ20700 LOC388495 19 similar to Calphotin CG4795-PA LRG SEMA6B 19p13.3 sema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6B MGC17791 19p13.3 hypothetical protein MGC17791 C19orf10 19p13.3 chromosome 19 open reading frame 10 DPP9 19p13.3 dipeptidylpeptidase 9 PGSF1 19p13.3 pituitary gland specific factor 1a FEM1A 19p13.3 fem-1 homolog a (C.elegans) TRIF 19p13.3 fem-1 homolog a (C.elegans) TIP47 LOC342959 19p13.3 similar to Hypothetical protein CBG18249 UHRF1 19p13.3 ubiquitin-like, containing PHD and RING finger domains, 1 KIAA0876
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
- - 3805 95.3 888 - Correa
  • being a type I transmembrane protein
  • - splicing 2005 57.5 517 - Correa
  • lacking the 3' portion of exon 12 through the 5' portion of exon 16 of variant SEMA6B3, a sequence that includes the stop codon used by SEMA6B3
  • having a different C-terminal sequence than SEMA6B3
  • lacking a transmembrane domain and is thought to be secreted
  • - splicing 2500 74.6 682 - Correa
  • lacking 1305 nt that are present within the last exon (16) of variant SEMA6B3, a sequence that includes the stop codon used by SEMA6B3
  • having a transmembrane domain
  • EXPRESSION
    Type restricted
    constitutive of
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Cardiovascularheart   lowly
    Digestiveintestinesmall intestine  highly
     stomach   moderately
    Nervousbrain   moderately
    Skin/Tegumentskin   moderately
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Muscular    
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    physiological period fetal
    Text fetal eyes
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • a SEMA domain
  • conjugated GlycoP
    HOMOLOGY
    interspecies ortholog to rattus Sema6b
    ortholog to murine Sema6b
    homolog to drosophila sema-1a
    homolog to C. elegans mab-20
    Homologene
    FAMILY
  • semaphorin family
  • CATEGORY transcription factor , signaling , receptor membrane
    SUBCELLULAR LOCALIZATION     plasma membrane
    text
  • integral to membrane
  • type I membrane protein
  • basic FUNCTION
  • acting as an axon guidance inhibitor
  • may play a role in both peripheral and central nervous system development
  • CELLULAR PROCESS nucleotide, transcription
    PHYSIOLOGICAL PROCESS development
    text
  • neurogenesis
  • PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    repressed by PPARs
    Other ATRA treatment (all-trans-retinoic acid)
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --low  
    downregulated in glioblastoma cell lines (treated by ATRA)
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS