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FLASH GENE
Symbol SEMA6B contributors: mct - updated : 25-08-2020
HGNC name sema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6B
HGNC id 10739
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • a SEMA domain
  • conjugated GlycoP
    HOMOLOGY
    interspecies ortholog to rattus Sema6b
    ortholog to murine Sema6b
    homolog to drosophila sema-1a
    homolog to C. elegans mab-20
    Homologene
    FAMILY
  • semaphorins axon-guidance family
  • CATEGORY transcription factor , signaling , receptor membrane
    SUBCELLULAR LOCALIZATION extracellular
        plasma membrane
    text
  • integral to membrane
  • type I membrane protein
  • basic FUNCTION
  • acting as an axon guidance inhibitor
  • may play a role in both peripheral and central nervous system development
  • CELLULAR PROCESS nucleotide, transcription
    PHYSIOLOGICAL PROCESS development
    text
  • neurogenesis
  • PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    repressed by PPARs
    Other ATRA treatment (all-trans-retinoic acid)
    ASSOCIATED DISORDERS
    corresponding disease(s) EPM11
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --low  
    downregulated in glioblastoma cell lines (treated by ATRA)
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
  • reliable biomarker for diagnosis, evaluation and gene-targeted therapy of gastric cancer
  • Therapy target
    ANIMAL & CELL MODELS