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FLASH GENE
Symbol SEMA6B contributors: mct - updated : 25-08-2020
HGNC name sema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6B
HGNC id 10739
EXPRESSION
Type restricted
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Cardiovascularheart   lowly
Digestiveintestinesmall intestine  highly
 stomach   moderately
Nervousbrainforebraincerebral cortex highly Homo sapiensAdult
 brainhindbraincerebellum   Homo sapiens
Skin/Tegumentskin   moderately
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Muscular    
cells
SystemCellPubmedSpeciesStageRna symbol
Nervousneuron Homo sapiens
NervousPurkinje cell Homo sapiens
cell lineage
cell lines
fluid/secretion
at STAGE
physiological period fetal
Text fetal eyes
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • a SEMA domain
  • conjugated GlycoP
    HOMOLOGY
    interspecies ortholog to rattus Sema6b
    ortholog to murine Sema6b
    homolog to drosophila sema-1a
    homolog to C. elegans mab-20
    Homologene
    FAMILY
  • semaphorins axon-guidance family
  • CATEGORY transcription factor , signaling , receptor membrane
    SUBCELLULAR LOCALIZATION extracellular
        plasma membrane
    text
  • integral to membrane
  • type I membrane protein
  • basic FUNCTION
  • acting as an axon guidance inhibitor
  • may play a role in both peripheral and central nervous system development
  • CELLULAR PROCESS nucleotide, transcription
    PHYSIOLOGICAL PROCESS development
    text
  • neurogenesis
  • PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    repressed by PPARs
    Other ATRA treatment (all-trans-retinoic acid)
    ASSOCIATED DISORDERS
    corresponding disease(s) EPM11
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --low  
    downregulated in glioblastoma cell lines (treated by ATRA)
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
  • reliable biomarker for diagnosis, evaluation and gene-targeted therapy of gastric cancer
  • Therapy target
    ANIMAL & CELL MODELS