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FLASH GENE
Symbol RNASET2 contributors: mct - updated : 25-06-2011
HGNC name ribonuclease T2
HGNC id 21686
Corresponding disease
LKCC leukoencephalopathy cystic, without megalencephaly
Location 6q27      Physical location : 167.343.007 - 167.370.077
Synonym name
  • ribonuclease,Rh/T2/S glycoprotein class, putative tumor suppressor gene
  • ribonuclease 6
  • ribonuclease T2
  • Synonym symbol(s) RTSRNASE, FLJ10907, RNASE6PL, bA514O12.3, RP11-514O12.3, FLJ42372
    EC.number 3.1.27.-
    DNA
    TYPE functioning gene
    STRUCTURE 27.07 kb     9 Exon(s)    1 Copie(s)
    MAPPING cloned Y linked N status provisional
    Physical map
    LOC346085 6q27 similar to Glyceraldehyde 3-phosphate dehydrogenase, liver (GAPDH) T 6q27 T, brachyury homolog (mouse) MGC35308 6q27 hypothetical protein MGC35308 C6orf83 6q27 chromosome 6 open reading frame 83 BRP44L 6q27 brain protein 44-like RPS6KA2 6q27 ribosomal protein S6 kinase, 90kDa, polypeptide 2 RNASET2 6q27 ribonuclease T2 FGFR1OP 6q27 FGFR1 oncogene partner CCR6 6q27 chemokine (C-C motif) receptor 6 GPR31 6q27 G protein-coupled receptor 31 LOC389448 6 similar to T-complex protein 10A homolog LOC391986 6 similar to unc-93 homolog A UNC93A 6q27 unc-93 homolog A (C. elegans) C6orf104 LOC389449 6 LOC389449 TCP10 6q26 t-complex 10 (mouse) LOC391987 6 similar to Serine palmitoyltransferase 2 (Long chain base biosynthesis protein 2) (LCB 2) (Serine-palmitoyl-CoA transferase 2) (SPT 2) C6orf123 6q27 chromosome 6 open reading frame 123 MLLT4 6q27 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 4 LOC202546 6q27 hypothetical LOC202546 C6orf54 6q27 chromosome 6 open reading frame 54 KIF25 6q27 kinesin family member 25 FRMD1 6q27 FERM domain containing 1 LOC389450 6 LOC389450 LOC154323 6q27 hypothetical LOC154323 MGC33437 6q27 meningioma expressed antigen 6 (coiled-coil proline-rich) pseudogene DACT2 6q27 dapper homolog 2, antagonist of beta-catenin (xenopus) SMOC2 6q27 SPARC related modular calcium binding 2
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    9 - 1250 29 256 - 2006 16620762
    EXPRESSION
    Type ubiquitous
    constitutive of
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Lymphoid/Immunespleen   highly
    Respiratoryrespiratory tractlarynx  highly
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • bipartite RNase motif
  • conjugated GlycoP
    HOMOLOGY
    Homologene
    FAMILY
  • RNase T2 family
  • widespread Rh/T2/S family of extracellular RNases
  • CATEGORY RNA associated , tumor suppressor
    SUBCELLULAR LOCALIZATION extracellular
        intracellular
    intracellular,cytoplasm,organelle,lysosome
    basic FUNCTION
  • having an interesting biological function in the control of tumourigenesis and metastatization
  • may be acting as tumor antagonizing/malignancy suppressor gene
  • behave as a class II tumor suppressor and abolish the tumorigenic potential of an ovarian cancer-derived cell line
  • cell growth regulator and it does not induce senescence in SV40 immortalized cell lines
  • modulate the tumor microenvironment to repress cancer growth
  • is a unique member of the growing family of tumor-antagonizing genes
  • possess a remarkable tumor suppressor activity (
  • CELLULAR PROCESS cell life, cell death/apoptosis
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism nucleic
    signaling
    RNA catabolism
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s) LKCC
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --low  
    in ovarian tumors
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target represents a new class of antitumorigenic and antiangiogenic drugs
    ANIMAL & CELL MODELS