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FLASH GENE
Symbol RNASET2 contributors: mct - updated : 25-06-2011
HGNC name ribonuclease T2
HGNC id 21686
EXPRESSION
Type ubiquitous
constitutive of
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Lymphoid/Immunespleen   highly
Respiratoryrespiratory tractlarynx  highly
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • bipartite RNase motif
  • conjugated GlycoP
    HOMOLOGY
    Homologene
    FAMILY
  • RNase T2 family
  • widespread Rh/T2/S family of extracellular RNases
  • CATEGORY RNA associated , tumor suppressor
    SUBCELLULAR LOCALIZATION extracellular
        intracellular
    intracellular,cytoplasm,organelle,lysosome
    basic FUNCTION
  • having an interesting biological function in the control of tumourigenesis and metastatization
  • may be acting as tumor antagonizing/malignancy suppressor gene
  • behave as a class II tumor suppressor and abolish the tumorigenic potential of an ovarian cancer-derived cell line
  • cell growth regulator and it does not induce senescence in SV40 immortalized cell lines
  • modulate the tumor microenvironment to repress cancer growth
  • is a unique member of the growing family of tumor-antagonizing genes
  • possess a remarkable tumor suppressor activity (
  • CELLULAR PROCESS cell life, cell death/apoptosis
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism nucleic
    signaling
    RNA catabolism
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s) LKCC
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --low  
    in ovarian tumors
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target represents a new class of antitumorigenic and antiangiogenic drugs
    ANIMAL & CELL MODELS