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FLASH GENE
Symbol RNASET2 contributors: mct - updated : 25-06-2011
HGNC name ribonuclease T2
HGNC id 21686
Corresponding disease
LKCC leukoencephalopathy cystic, without megalencephaly
Location 6q27      Physical location : 167.343.007 - 167.370.077
Synonym name
  • ribonuclease,Rh/T2/S glycoprotein class, putative tumor suppressor gene
  • ribonuclease 6
  • ribonuclease T2
  • Synonym symbol(s) RTSRNASE, FLJ10907, RNASE6PL, bA514O12.3, RP11-514O12.3, FLJ42372
    EC.number 3.1.27.-
    DNA
    TYPE functioning gene
    STRUCTURE 27.07 kb     9 Exon(s)    1 Copie(s)
    MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    9 - 1250 29 256 - 2006 16620762
    EXPRESSION
    Type ubiquitous
    constitutive of
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Lymphoid/Immunespleen   highly
    Respiratoryrespiratory tractlarynx  highly
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • bipartite RNase motif
  • conjugated GlycoP
    HOMOLOGY
    Homologene
    FAMILY
  • RNase T2 family
  • widespread Rh/T2/S family of extracellular RNases
  • CATEGORY RNA associated , tumor suppressor
    SUBCELLULAR LOCALIZATION extracellular
        intracellular
    intracellular,cytoplasm,organelle,lysosome
    basic FUNCTION
  • having an interesting biological function in the control of tumourigenesis and metastatization
  • may be acting as tumor antagonizing/malignancy suppressor gene
  • behave as a class II tumor suppressor and abolish the tumorigenic potential of an ovarian cancer-derived cell line
  • cell growth regulator and it does not induce senescence in SV40 immortalized cell lines
  • modulate the tumor microenvironment to repress cancer growth
  • is a unique member of the growing family of tumor-antagonizing genes
  • possess a remarkable tumor suppressor activity (
  • CELLULAR PROCESS cell life, cell death/apoptosis
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism nucleic
    signaling
    RNA catabolism
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s) LKCC
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --low  
    in ovarian tumors
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target represents a new class of antitumorigenic and antiangiogenic drugs
    ANIMAL & CELL MODELS