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FLASH GENE
Symbol RNASEH2A contributors: mct - updated : 17-01-2012
HGNC name ribonuclease H2, large subunit
HGNC id 18518
Corresponding disease
AGS4 Aicardi-Goutieres syndrome 4
Location 19p13.2      Physical location : 12.917.427 - 12.924.462
Synonym symbol(s) RNHL, RNHIA, RNASEHI, JUNB
EC.number 3.1.26.4
DNA
TYPE functioning gene
STRUCTURE 7.03 kb     8 Exon(s)
10 Kb 5' upstream gene genomic sequence study
MAPPING cloned Y linked N status provisional
Physical map
ZNF442 19p13.13 zinc finger protein 442 LOC388510 19 LOC388510 LOC90576 19p13.2 hypothetical protein LOC90576 ZNF443 19p13.13 zinc finger protein 443 FLJ38281 19p13.2 hypothetical protein FLJ38281 MGC26914 19p13.2 hypothetical protein MGC26914 PGK1P2 6p21-p12 phosphoglycerate kinase 1, pseudogene 2 ZNF490 19p13.2 zinc finger protein 490 FLJ90396 19p13.2 hypothetical protein FLJ90396 MGC4238 19p13.2 hypothetical protein MGC4238 LOC284393 19p13.2 similar to 60S ribosomal protein L10 (QM protein homolog) MAN2B1 19p13.2-p13.1 mannosidase, alpha, class 2B, member 1 PTD008 19p13.2 PTD008 protein DHPS 19p13.12-p13.11 deoxyhypusine synthase MGC10870 19p13.2 hypothetical protein MGC10870 TNPO2 19p13.2 transportin 2 (importin 3, karyopherin beta 2b) MGC2803 19p13.2 hypothetical protein MGC2803 ASNA1 19q13.3 arsA arsenite transporter, ATP-binding, homolog 1 (bacterial) VMD2L1 19p13.2-p13.12 arsA arsenite transporter, ATP-binding, homolog 1 (bacterial) HOOK2 19p13.2 arsA arsenite transporter, ATP-binding, homolog 1 (bacterial) RNASEH2A 19p13.2 ribonuclease H2, large subunit JUNB 19p13.2 jun B proto-oncogene PRDX2 13q12 peroxiredoxin 2 RTBDN 19p12 retbindin DNASE2 19p13.2 deoxyribonuclease II, lysosomal KLF1 19p13.13-p13.12 Kruppel-like factor 1 (erythroid) GCDH 19p13.2 glutaryl-Coenzyme A dehydrogenase FARSLA 19p13.2 phenylalanine-tRNA synthetase-like, alpha subunit CALR 19p13.3-p13.2 calreticulin RAD23A 19p13.2 RAD23 homolog A (S. cerevisiae) PLINP-1 19p13.2 papillomavirus L2 interacting nuclear protein 1 FLJ38607 19p13.2 hypothetical protein FLJ38607 LOC339375 19p13.13 hypothetical LOC339375 NFIX 19p13.2 nuclear factor I/X (CCAAT-binding transcription factor) LYL1 19p13.2-p13.1 lymphoblastic leukemia derived sequence 1 FLJ20244 19p13.13 hypothetical protein FLJ20244 BTBD14B 19p13.13 BTB (POZ) domain containing 14B
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
8 - 1148 - 299 - 1998 9789007
EXPRESSION
Type
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Lymphoid/Immunetonsils   highly
Reproductivefemale systemuteruscervix highly
Skin/Tegumentskin   highly
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • C terminus is a eukaryotic adaptation for binding the two accessory subunits, with residues within it required for enzymatic activity and this C-terminal extension interacts with the RNASEH2C C terminus and both are necessary to form a stable, enzymatically active heterotrimer
  • HOMOLOGY
    Homologene
    FAMILY RNASE HII family, eukaryotic subfamily
    CATEGORY enzyme
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,cytosolic,ribosome
    intracellular,nucleus
    basic FUNCTION
  • endonuclease that specifically degrades the RNA of RNA- DNA hybrids
  • participating in DNA replication
  • may function to degrade RNA/DNA hybrids during cell death to avoid nucleic acid-mediated immune activation
  • ribonuclease H enzymes that specifically recognize RNA/DNA hybrids and hydrolyze the ribonucleotide-containing polynucleotide strand
  • SAMHD1, TREX1, and RNase H2 participate in a cellular nucleic acid metabolic pathway that overlaps the interferon-mediated innate antiviral and inflammatory responses
  • RNASEH1, RNASEH2A are necessary for the removal of RNA that is found in DNA
  • RNase H2 removes singly incorporated ribonucleoside 5-monophosphate (rNMP) residues in DNA
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component RNase H2 is a heterotrimeric complex of the RNase H2A, RNase H2B, and RNase H2C proteins that are all required for proper function and activity
    INTERACTION
    DNA
    RNA
    small molecule metal binding,
    manganese or magnesium
    protein
  • interfaces mostly with the RNase H2C subunit that is intricately interwoven with the RNase H2B subunit
  • C1QBP binds specifically to human RNASEH1, but not human RNASEH2A
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s) AGS4
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS