basic FUNCTION
| endonuclease that specifically degrades the RNA of RNA- DNA hybrids |
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participating in DNA replication |
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may function to degrade RNA/DNA hybrids during cell death to avoid nucleic acid-mediated immune activation |
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ribonuclease H enzymes that specifically recognize RNA/DNA hybrids and hydrolyze the ribonucleotide-containing polynucleotide strand |
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SAMHD1, TREX1, and RNase H2 participate in a cellular nucleic acid metabolic pathway that overlaps the interferon-mediated innate antiviral and inflammatory responses |
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RNASEH1, RNASEH2A are necessary for the removal of RNA that is found in DNA |
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RNase H2 removes singly incorporated ribonucleoside 5’-monophosphate (rNMP) residues in DNA |